Comparative Experimental Infection Study in Dogs with Ehrlichia canis, E. chaffeensis, Anaplasma platys and A. phagocytophilum

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dc.contributor.author Nair, Arathy D.S.
dc.contributor.author Cheng, C.
dc.contributor.author Ganta, Chanran K.
dc.contributor.author Sanderson, Michael W.
dc.contributor.author Alleman, A. R.
dc.contributor.author Munderloh, U. G.
dc.contributor.author Ganta, Roman R.
dc.date.accessioned 2016-09-20T17:34:04Z
dc.date.available 2016-09-20T17:34:04Z
dc.date.issued 2016-02-02
dc.identifier.uri http://hdl.handle.net/2097/34062
dc.description Citation: Nair, A. D. S., Cheng, C., Ganta, C. K., Sanderson, M. W., Alleman, A. R., Munderloh, U. G., & Ganta, R. R. (2016). Comparative Experimental Infection Study in Dogs with Ehrlichia canis, E. chaffeensis, Anaplasma platys and A. phagocytophilum. Plos One, 11(2), 21. doi:10.1371/journal.pone.0148239
dc.description.abstract Dogs acquire infections with the Anaplasmataceae family pathogens, E. canis, E. chaffeensis, E. ewingii, A. platys and A. phagocytophilum mostly during summer months when ticks are actively feeding on animals. These pathogens are also identified as causing diseases in people. Despite the long history of tick-borne diseases in dogs, much remains to be defined pertaining to the clinical and pathological outcomes of infections with these pathogens. In the current study, we performed experimental infections in dogs with E. canis, E. chaffeensis, A. platys and A. phagocytophilum. Animals were monitored for 42 days to evaluate infection-specific clinical, hematological and pathological differences. All four pathogens caused systemic persistent infections detectible throughout the 6 weeks of infection assessment. Fever was frequently detected in animals infected with E. canis, E. chaffeensis, and A. platys, but not in dogs infected with A. phagocytophilum. Hematological differences were evident in all four infected groups, although significant overlap existed between the groups. A marked reduction in packed cell volume that correlated with reduced erythrocytes and hemoglobin was observed only in E. canis infected animals. A decline in platelet numbers was common with E. canis, A. platys and A. phagocytophilum infections. Histopathological lesions in lung, liver and spleen were observed in all four groups of infected dogs; infection with E. canis had the highest pathological scores, followed by E. chaffeensis, then A. platys and A. phagocytophilum. All four pathogens induced IgG responses starting on day 7 post infection, which was predominantly comprised of IgG2 subclass antibodies. This is the first detailed investigation comparing the infection progression and host responses in dogs after inoculation with four pathogens belonging to the Anaplasmataceae family. The study revealed a significant overlap in clinical, hematological and pathological changes resulting from the infections.
dc.relation.uri https://doi.org/10.1371/journal.pone.0148239
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Serum Antiplatelet Antibodies
dc.subject Monocytic Ehrlichiosis
dc.subject Cyclic
dc.subject Thrombocytopenia
dc.subject Humoral Immunity
dc.subject Nested Pcr
dc.title Comparative Experimental Infection Study in Dogs with Ehrlichia canis, E. chaffeensis, Anaplasma platys and A. phagocytophilum
dc.type Article
dc.date.published 2016
dc.citation.doi 10.1371/journal.pone.0148239
dc.citation.issn 1932-6203
dc.citation.issue 2
dc.citation.jtitle Plos One
dc.citation.spage 21
dc.citation.volume 11
dc.contributor.authoreid arathy
dc.contributor.authoreid ckganta
dc.contributor.authoreid sandersn
dc.contributor.authoreid rganta


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