Differential Rearing Alters Forced Swim Test Behavior, Fluoxetine Efficacy, and Post-Test Weight Gain in Male Rats

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dc.contributor.author Arndt, D. L.
dc.contributor.author Peterson, C. J.
dc.contributor.author Cain, Mary E.
dc.date.accessioned 2016-04-06T15:16:25Z
dc.date.available 2016-04-06T15:16:25Z
dc.identifier.uri http://hdl.handle.net/2097/32473
dc.description Citation: Arndt, D. L., Peterson, C. J., & Cain, M. E. (2015). Differential Rearing Alters Forced Swim Test Behavior, Fluoxetine Efficacy, and Post-Test Weight Gain in Male Rats. Plos One, 10(7), 21. doi:10.1371/journal.pone.0131709
dc.description Environmental factors play a key role in the etiology of depression. The rodent forced swim test (FST) is commonly used as a preclinical model of depression, with increases in escape-directed behavior reflecting antidepressant effects, and increases in immobility reflecting behavioral despair. Environmental enrichment leads to serotonergic alterations in rats, but it is unknown whether these alterations may influence the efficacy of common antidepressants. Male Sprague-Dawley rats were reared in enriched (EC), standard (SC), or isolated (IC) conditions. Following the rearing period, fluoxetine (10 or 20 mg/kg, i.p.) was administered 23.5 hrs, 5 hrs, and 1 hr before locomotor and FST measures. Following locomotor testing and FST exposure, rats were weighed to assess fluoxetine-, FST-, and environmental condition-induced moderations in weight gain. Results revealed an antidepressant effect of environmental enrichment and a depressant effect of isolation. Regardless of significant fluoxetine effects on locomotor activity, fluoxetine generally decreased swimming and increased immobility in all three environmental conditions, with IC-fluoxetine (10 mg/kg) rats and EC-fluoxetine (20 mg/kg) rats swimming less than vehicle counterparts. Subchronic 20 mg/kg fluoxetine also induced significant weight loss, and differential rearing appeared to moderate weight gain following FST stress. These results suggest that differential rearing has the ability to alter FST behaviors, fluoxetine efficacy, and post-stressor well-being. Moreover, 20 mg/kg fluoxetine, administered subchronically, may lead to atypical effects of those commonly observed in the FST, highlighting the importance and impact of both environmental condition and dosing regimen in common animal models of depression.
dc.relation.uri https://doi.org/10.1371/journal.pone.0131709
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject Messenger-Rna Expression
dc.subject Hypothalamic 5-Ht1A Receptors
dc.subject Depressive-Like
dc.subject Behavior
dc.subject Environmental-Enrichment
dc.subject Social-Isolation
dc.title Differential Rearing Alters Forced Swim Test Behavior, Fluoxetine Efficacy, and Post-Test Weight Gain in Male Rats
dc.type Article
dc.date.published 2015
dc.citation.doi 10.1371/journal.pone.0131709
dc.citation.issn 1932-6203
dc.citation.issue 7
dc.citation.jtitle PLoS One
dc.citation.spage 21
dc.citation.volume 10
dc.contributor.authoreid mecain


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