Tissue Barriers to Arbovirus Infection in Mosquitoes

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dc.contributor.author Franz, A. W. E.
dc.contributor.author Kantor, A. M.
dc.contributor.author Passarelli, A. L.
dc.contributor.author Clem, Rollie J.
dc.date.accessioned 2016-04-04T22:13:44Z
dc.date.available 2016-04-04T22:13:44Z
dc.identifier.uri http://hdl.handle.net/2097/32226
dc.description Citation: Franz, A. W. E., Kantor, A. M., Passarelli, A. L., & Clem, R. J. (2015). Tissue Barriers to Arbovirus Infection in Mosquitoes. Viruses-Basel, 7(7), 3741-3767. doi:10.3390/v7072795
dc.description Arthropod-borne viruses (arboviruses) circulate in nature between arthropod vectors and vertebrate hosts. Arboviruses often cause devastating diseases in vertebrate hosts, but they typically do not cause significant pathology in their arthropod vectors. Following oral acquisition of a viremic bloodmeal from a vertebrate host, the arbovirus disease cycle requires replication in the cellular environment of the arthropod vector. Once the vector has become systemically and persistently infected, the vector is able to transmit the virus to an uninfected vertebrate host. In order to systemically infect the vector, the virus must cope with innate immune responses and overcome several tissue barriers associated with the midgut and the salivary glands. In this review we describe, in detail, the typical arbovirus infection route in competent mosquito vectors. Based on what is known from the literature, we explain the nature of the tissue barriers that arboviruses are confronted with in a mosquito vector and how arboviruses might surmount these barriers. We also point out controversial findings to highlight particular areas that are not well understood and require further research efforts.
dc.relation.uri https://doi.org/10.3390/v7072795
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject Arbovirus
dc.subject Mosquito
dc.subject Midgut
dc.subject Dissemination
dc.subject Salivary Gland
dc.subject Tissue
dc.title Tissue Barriers to Arbovirus Infection in Mosquitoes
dc.type Article
dc.date.published 2015
dc.citation.doi 10.3390/v7072795
dc.citation.epage 3767
dc.citation.issn 1999-4915
dc.citation.issue 7
dc.citation.jtitle Viruses-Basel
dc.citation.spage 3741
dc.citation.volume 7
dc.contributor.authoreid lpassar
dc.contributor.authoreid rclem


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