Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis

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dc.contributor.author He, C. L.
dc.contributor.author Lin, Zhoumeng
dc.contributor.author Robb, S. W.
dc.contributor.author Ezeamama, A. E.
dc.date.accessioned 2016-03-28T19:12:18Z
dc.date.available 2016-03-28T19:12:18Z
dc.identifier.uri http://hdl.handle.net/2097/32182
dc.description Citation: He, C. L., Lin, Z., Robb, S. W., & Ezeamama, A. E. (2015). Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis. Nutrients, 7(6), 4555-4577. doi:10.3390/nu7064555
dc.description Vitamin D deficiency (VDD) is common in women with and without polycystic ovary syndrome (PCOS) and may be associated with metabolic and endocrine disorders in PCOS. The aim of this meta-analysis is to assess the associations of serum vitamin D levels with metabolic and endocrine dysregulations in women with PCOS, and to determine effects of vitamin D supplementation on metabolic and hormonal functions in PCOS patients. The literature search was undertaken through five databases until 16 January 2015 for both observational and experimental studies concerning relationships between vitamin D and PCOS. A total of 366 citations were identified, of which 30 were selected (n = 3182). We found that lower serum vitamin D levels were related to metabolic and hormonal disorders in women with PCOS. Specifically, PCOS patients with VDD were more likely to have dysglycemia (e.g., increased levels of fasting glucose and homeostatic model assessment-insulin resistance index (HOMA-IR)) compared to those without VDD. This meta-analysis found no evidence that vitamin D supplementation reduced or mitigated metabolic and hormonal dysregulations in PCOS. VDD may be a comorbid manifestation of PCOS or a minor pathway in PCOS associated metabolic and hormonal dysregulation. Future prospective observational studies and randomized controlled trials with repeated VDD assessment and better characterization of PCOS disease severity at enrollment are needed to clarify whether VDD is a co-determinant of hormonal and metabolic dysregulations in PCOS, represents a consequence of hormonal and metabolic dysregulations in PCOS or both.
dc.relation.uri https://doi.org/10.3390/nu7064555
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject Vitamin D
dc.subject Polycystic Ovary Syndrome
dc.subject Metabolic And Endocrine Disorders
dc.subject Systematic Review And Meta-Analysis
dc.subject D-Receptor Gene
dc.subject Insulin-Resistance
dc.title Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis
dc.type Article
dc.date.published 2015
dc.citation.doi 10.3390/nu7064555
dc.citation.epage 4577
dc.citation.issn 2072-6643
dc.citation.issue 6
dc.citation.jtitle Nutrients
dc.citation.spage 4555
dc.citation.volume 7
dc.contributor.authoreid zhoumeng


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Attribution 4.0 International (CC BY 4.0) Except where otherwise noted, the use of this item is bound by the following: Attribution 4.0 International (CC BY 4.0)

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