Influence of NleH effector expression, host genetics, and inflammation on Citrobacter rodentium colonization of mice

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dc.contributor.author Feuerbacher, Leigh Ann
dc.contributor.author Hardwidge, Philip R.
dc.date.accessioned 2014-11-14T17:26:29Z
dc.date.available 2014-11-14T17:26:29Z
dc.date.issued 2014-11-14
dc.identifier.uri http://hdl.handle.net/2097/18677
dc.description.abstract The Escherichia coli NleH1 and NleH2 virulence proteins differentially regulate host transcription of innate immunity genes. The mouse pathogen Citrobacter rodentium encodes one NleH protein, which functions equivalently to E. coli NleH1. We examined the impact of host genetics and intestinal inflammation on the contribution of NleH to C. rodentium colonization of mice differing in LPS responsiveness. NleH expression was detrimental to C. rodentium in C57BL/10ScNJ mice, which do not mount LPS-induced inflammatory responses. This phenotype was reversed if inflammation was induced by chemical means. C. rodentium that expressed both E. coli NleH1 and NleH2 was hypervirulent in C3H/HeJ mice. en_US
dc.language.iso en_US en_US
dc.relation.uri http://www.sciencedirect.com/science/article/pii/S1286457914000173 en_US
dc.subject Escherichia coli en_US
dc.subject Innate immunity en_US
dc.subject NF-kappa B (NF-κB) en_US
dc.subject NleH1 en_US
dc.subject Mouse en_US
dc.title Influence of NleH effector expression, host genetics, and inflammation on Citrobacter rodentium colonization of mice en_US
dc.type Article (author version) en_US
dc.date.published 2014 en_US
dc.citation.doi doi:10.1016/j.micinf.2014.02.003 en_US
dc.citation.epage 433 en_US
dc.citation.issue 5 en_US
dc.citation.jtitle Microbes and Infection en_US
dc.citation.spage 429 en_US
dc.citation.volume 16 en_US
dc.contributor.authoreid feuerbac en_US
dc.contributor.authoreid philiphardwidge en_US


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