Altering physical properties of pharmaceutical co-crystals in a systematic manner

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dc.contributor.author Aakeröy, Christer B.
dc.contributor.author Forbes, Safiyyah
dc.contributor.author Desper, John
dc.date.accessioned 2014-08-15T14:11:40Z
dc.date.available 2014-08-15T14:11:40Z
dc.date.issued 2014-03-05
dc.identifier.uri http://hdl.handle.net/2097/18238
dc.description.abstract Systematic structure-property studies on a series of co-crystals of potential cancer drugs with aliphatic dicarboxylic acids were undertaken. This study reveals that systematic changes to the molecular nature of the co-crystallizing agent combined with control over the way individual building blocks are organized within the crystalline lattice makes it possible to establish predictable links between molecular structure and macroscopic physical properties, such as melting behaviour and aqueous solubility. However, it is not possible to find any notable correlation between physical properties-chemical compositions in the absence of structural consistency. en_US
dc.language.iso en_US en_US
dc.relation.uri http://doi.org/10.1039/c4ce00206g en_US
dc.rights This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.rights.uri https://rightsstatements.org/page/InC/1.0/?language=en
dc.subject Co-crystals en_US
dc.subject Cancer drugs en_US
dc.subject Molecular structure en_US
dc.title Altering physical properties of pharmaceutical co-crystals in a systematic manner en_US
dc.type Article (author version) en_US
dc.date.published 2014 en_US
dc.citation.doi 10.1039/c4ce00206g en_US
dc.citation.epage 5877 en_US
dc.citation.issue 26 en_US
dc.citation.jtitle CrystEngComm en_US
dc.citation.spage 5870 en_US
dc.citation.volume 16 en_US
dc.contributor.authoreid aakeroy en_US
dc.contributor.authoreid desperj en_US


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This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). Except where otherwise noted, the use of this item is bound by the following: This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).

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