Normal glucose metabolism in carnivores overlaps with diabetes pathology in non-carnivores

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Show simple item record Schermerhorn, Thomas 2014-08-04T16:29:29Z 2014-08-04T16:29:29Z 2014-08-04
dc.description.abstract Carnivores, such as the dolphin and the domestic cat, have numerous adaptations that befit consumption of diets with high protein and fat content, with little carbohydrate content. Consequently, nutrient metabolism in carnivorous species differs substantially from that of non-carnivores. Important metabolic pathways known to differ between carnivores and non-carnivores are implicated in the development of diabetes and insulin resistance in non-carnivores: (1) the hepatic glucokinase (GCK) pathway is absent in healthy carnivores yet GCK deficiency may result in diabetes in rodents and humans, (2) healthy dolphins and cats are prone to periods of fasting hyperglycemia and exhibit insulin resistance, both of which are risk factors for diabetes in non-carnivores. Similarly, carnivores develop naturally occurring diseases such as hemochromatosis, fatty liver, obesity, and diabetes that have strong parallels with the same disorders in humans. Understanding how evolution, environment, diet, and domestication may play a role with nutrient metabolism in the dolphin and cat may also be relevant to human diabetes. en_US
dc.language.iso en_US en_US
dc.relation.uri en_US
dc.subject Feline en_US
dc.subject Dolphin en_US
dc.subject Liver en_US
dc.subject Pancreas en_US
dc.subject Nutrition en_US
dc.subject Carbohydrate en_US
dc.subject Protein en_US
dc.subject Animal models en_US
dc.title Normal glucose metabolism in carnivores overlaps with diabetes pathology in non-carnivores en_US
dc.type Article (publisher version) en_US 2013 en_US
dc.citation.doi doi:10.3389/fendo.2013.00188 en_US
dc.citation.jtitle Frontiers in Endocrinology en_US
dc.citation.spage Article 188 en_US
dc.citation.volume 4 en_US
dc.contributor.authoreid tscherme en_US

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