DDE and PCB serum concentration in maternal blood and their adult female offspring

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dc.contributor.author Hsu, Wei-Wen
dc.contributor.author Osuch, Janet Rose
dc.contributor.author Todem, David
dc.contributor.author Taffe, Bonita
dc.contributor.author O’Keefe, Michael
dc.contributor.author Adera, Selamawit
dc.contributor.author Karmaus, Wilfried
dc.date.accessioned 2014-07-16T20:36:01Z
dc.date.available 2014-07-16T20:36:01Z
dc.date.issued 2014-07-16
dc.identifier.uri http://hdl.handle.net/2097/17923
dc.description.abstract Background: Dichlorodiphenyl dichloroethylene (DDE) and polychlorinated biphenyls (PCBs) can be passed from mother to offspring through placental transfer or breast feeding. Unknown is whether maternal levels can predict concentrations in adult offspring. Objectives: To test the association between maternal blood levels of DDE and PCBs and adult female offspring levels of these compounds using data from the Michigan Fisheaters’Cohort. Methods: DDE and PCB concentrations were determined in 132 adult daughters from 84 mothers. Prenatal exposures were estimated based on maternal DDE and PCB serum levels measured between 1973 and 1991. Levels in adult daughters were regressed on maternal and estimated prenatal exposure levels, adjusting for potential confounders using linear mixed models. Confounders included daughter’s age, birth order, birth weight, number of pregnancies, the length of time the daughter was breast-fed, the length of time the daughter breast-fed her own children, last year fish-eating status, body mass index, and lipid weight. Results: The median age of the participants was 40.4 years (range 18.4 to 65.4, 5–95 percentiles 22.5-54.6%, respectively). Controlling for confounders and intra-familial associations, DDE and PCB concentrations in adult daughters were significantly positively associated with estimated prenatal levels and with maternal concentrations. The proportion of variance in the adult daughters’ organochlorine concentrations explained by the maternal exposure levels is approximately 23% for DDE and 43% for PCBs. The equivalent of a median of 3.67 μg/L prenatal DDE and a median of 2.56 μg/L PCBs were 15.64 and 10.49 years of fish consumption, respectively. When controlling for effects of the shared environment (e.g., fish diet) by using a subsample of paternal levels measured during the same time frames (n=53 and n=37), we determined that the direct maternal transfer remains important. Conclusions: Estimated intrauterine DDE and PCB levels predicted concentrations in adult female offspring 40 years later. Interpretation of adverse health effects from intrauterine exposures of persistent pollutants may need to consider the sustained impact of maternal DDE and PCB levels found in their offspring. en_US
dc.language.iso en_US en_US
dc.relation.uri http://www.sciencedirect.com/science/article/pii/S0013935114000553 en_US
dc.subject Intra-uterine exposure en_US
dc.subject Dichlorodiphenyl dichloroethylene en_US
dc.subject Polychlorinated biphenyls en_US
dc.subject Sport-caught fish consumption en_US
dc.subject Female offspring en_US
dc.title DDE and PCB serum concentration in maternal blood and their adult female offspring en_US
dc.type Article (author version) en_US
dc.date.published 2014 en_US
dc.citation.doi doi:10.1016/j.envres.2014.03.009 en_US
dc.citation.epage 390 en_US
dc.citation.jtitle Environmental Research en_US
dc.citation.spage 384 en_US
dc.citation.volume 132 en_US
dc.contributor.authoreid wwhsu en_US

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