Blockade of CB1 receptors prevents retention of extinction but does not increase low pre-incubated conditioned fear in the fear incubation procedure

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dc.contributor.author Pickens, Charles L.
dc.contributor.author Theberge, Florence R.
dc.date.accessioned 2014-06-24T20:40:09Z
dc.date.available 2014-06-24T20:40:09Z
dc.date.issued 2014-02-01
dc.identifier.uri http://hdl.handle.net/2097/17881
dc.description.abstract We recently developed a procedure to study fear incubation in which rats given 100 tone-shock pairings over 10 days show low fear 2 days after conditioned fear training and high fear after 30 days. Notably, fear 2 days after 10 sessions of fear conditioning is lower than fear seen 2 days after a single session of fear conditioning, suggesting that fear is suppressed. Here, we investigate the potential role of CB1 receptor activation by endocannabinoids in this fear suppression. We gave rats 10 days of fear conditioning and then gave systemic injections of the CB1 receptor antagonist SR141716 before a conditioned fear test conducted 2 days later under extinction conditions. A second test was conducted without any injections on the following day (3 days post-training) to examine fear extinction retention. SR141716 injections did not increase fear expression 2 days after extended fear conditioning or affect within-session extinction, but impaired retention of between-session fear extinction in the day 3 test. These data suggest that CB1 receptor activation is not suppressing fear soon after extended fear conditioning in the fear incubation task. The data also add to an existing literature on the effects of CB1 receptors in extinction of conditioned fear. en_US
dc.language.iso en_US en_US
dc.relation.uri http://doi.org/10.1097/FBP.0000000000000020 en_US
dc.rights This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). en_US
dc.rights.uri http://rightsstatements.org/vocab/InC/1.0/
dc.subject Fear incubation en_US
dc.subject Fear conditioning en_US
dc.subject PTSD en_US
dc.subject CB1 en_US
dc.subject Endocannabinoids en_US
dc.subject Rimonabant en_US
dc.title Blockade of CB1 receptors prevents retention of extinction but does not increase low pre-incubated conditioned fear in the fear incubation procedure en_US
dc.type Article (author version) en_US
dc.date.published 2014 en_US
dc.citation.doi 10.1097/FBP.0000000000000020 en_US
dc.citation.epage 31 en_US
dc.citation.issue 1 en_US
dc.citation.jtitle Behavioural Pharmacology en_US
dc.citation.spage 23 en_US
dc.citation.volume 25 en_US
dc.contributor.authoreid pickens en_US


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