Comparison of antimicrobial susceptibility among Clostridium difficile isolated from an integrated human and swine population in Texas

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dc.contributor.author Norman, Keri N.
dc.contributor.author Scott, Harvey Morgan
dc.contributor.author Harvey, Roger B.
dc.contributor.author Norby, Bo
dc.contributor.author Hume, Michael E.
dc.date.accessioned 2014-06-24T20:35:01Z
dc.date.available 2014-06-24T20:35:01Z
dc.date.issued 2014-03-28
dc.identifier.uri http://hdl.handle.net/2097/17880
dc.description.abstract Clostridium difficile can be a major problem in hospitals because the bacterium primarily affects individuals with an altered intestinal flora; this largely occurs through prolonged antibiotic use. Proposed sources of increased community-acquired infections are food animals and retail meats. The objective of this study was to compare the antimicrobial resistance patterns of C. difficile isolated from a closed, integrated population of humans and swine to increase understanding of the bacterium in these populations. Swine fecal samples were collected from a vertically flowing swine population consisting of farrowing, nursery, breeding, and grower/finisher production groups. Human wastewater samples were collected from swine worker and non-worker occupational group cohorts. Antimicrobial susceptibility testing was performed on 523 C. difficile strains from the population using commercially available agar diffusion Epsilometer test (Etest®) for 11 different antimicrobials. All of the swine and human strains were susceptible to amoxicillin/clavulanic acid, piperacillin/tazobactam, and vancomycin. In addition, all the human strains were susceptible to chloramphenicol. The majority of the human and swine strains were resistant to cefoxitin and ciprofloxacin. Statistically significant differences in antimicrobial susceptibility were found among the swine production groups for ciprofloxacin, tetracycline, amoxicillin/clavulanic acid, and clindamycin. No significant differences in antimicrobial susceptibility were found across human occupational group cohorts. We found that 8.3% of the swine strains and 13.3% of the human strains exhibited resistance to metronidazole. The finding of differences in susceptibility patterns between human and swine strains of C. difficile, provides evidence that transmission between host species in this integrated population is unlikely. en_US
dc.language.iso en_US en_US
dc.relation.uri http://doi.org/10.1089/fpd.2013.1648 en_US
dc.rights This is a copy of an article published in Foodborne Pathogens and Disease © 2014 Mary Ann Liebert, Inc.; Foodborne Pathogens and Disease is available online at: http://online.liebertpub.com. en_US
dc.subject Clostridium difficile en_US
dc.subject Intestinal flora en_US
dc.subject Antimicrobial resistance en_US
dc.subject Antimicrobial susceptibility en_US
dc.title Comparison of antimicrobial susceptibility among Clostridium difficile isolated from an integrated human and swine population in Texas en_US
dc.type Article (author version) en_US
dc.date.published 2014 en_US
dc.citation.doi 10.1089/fpd.2013.1648 en_US
dc.citation.epage 264 en_US
dc.citation.issue 4 en_US
dc.citation.jtitle Foodborne Pathogens and Disease en_US
dc.citation.spage 257 en_US
dc.citation.volume 11 en_US
dc.contributor.authoreid hmscott en_US


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