Inhibition of long chain fatty acyl-CoA synthetase (ACSL) and ischemia reperfusion injury

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dc.contributor.author Prior, Allan M.
dc.contributor.author Zhang, Man
dc.contributor.author Blakeman, Nina
dc.contributor.author Datta, Palika
dc.contributor.author Pham, Hung
dc.contributor.author Chen, Qian
dc.contributor.author Young, Lindon H.
dc.contributor.author Weis, Margaret T.
dc.contributor.author Hua, Duy H.
dc.date.accessioned 2014-05-30T13:25:47Z
dc.date.available 2014-05-30T13:25:47Z
dc.date.issued 2014-02-15
dc.identifier.uri http://hdl.handle.net/2097/17802
dc.description.abstract Various triacsin C analogs, containing different alkenyl chains and carboxylic acid bioisoteres including 4-aminobenzoic acid, isothiazolidine dioxide, hydroxylamine, hydroxytriazene, and oxadiazolidine dione, were synthesized and their inhibitions of long chain fatty acyl-CoA synthetase (ACSL) were examined. Two methods, a cell-based assay of ACSL activity and an in situ [¹⁴C]-palmitate incorporation into extractable lipids were used to study the inhibition. Using an in vivo leukocyte recruitment inhibition protocol, the translocation of one or more cell adhesion molecules from the cytoplasm to the plasma membrane on either the endothelium or leukocyte or both was inhibited by inhibitors 1, 9, and triacsin C. The results suggest that inhibition of ACSL may attenuate the vascular inflammatory component associated with ischemia reperfusion injury and lead to a decrease of infarct expansion. en_US
dc.language.iso en_US en_US
dc.relation.uri http://doi.org/10.1016/j.bmcl.2014.01.016 en_US
dc.rights This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.rights.uri http://rightsstatements.org/vocab/InC/1.0/
dc.subject Hydroxytriazene en_US
dc.subject Ischemia reperfusion injury en_US
dc.subject Long chain fatty acyl-CoA synthetase (ACSL) en_US
dc.subject Inhibitors en_US
dc.subject Oxadiazolidine dione en_US
dc.subject Triacsin C en_US
dc.title Inhibition of long chain fatty acyl-CoA synthetase (ACSL) and ischemia reperfusion injury en_US
dc.type Article (author version) en_US
dc.date.published 2014 en_US
dc.citation.doi 10.1016/j.bmcl.2014.01.016 en_US
dc.citation.epage 1061 en_US
dc.citation.issue 4 en_US
dc.citation.jtitle Bioorganic and Medicinal Chemistry Letters en_US
dc.citation.spage 1057 en_US
dc.citation.volume 24 en_US
dc.contributor.authoreid duy en_US


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