Viruses of the family Bunyaviridae: are all available isolates reassortants?

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Show simple item record Briese, Thomas Calisher, Charles H. Higgs, Stephen 2014-05-01T19:38:18Z 2014-05-01T19:38:18Z 2014-05-01
dc.description.abstract Viruses of the family Bunyaviridae (the bunyaviruses) possess three distinct linear, single-stranded, negative sense or ambisense RNA segments (large, medium, and small). Dual infections of arthropod and perhaps vertebrate and plant hosts provide substantial opportunity for segment reassortment and an increasingly recognized number of the nearly 300 viruses in this family have been shown to be reassortants. Reassortment of RNA segments (genetic shift) complements genetic drift (accumulation of point mutations) as a powerful mechanism underlying bunyavirus evolution. Here we consider the possibility, if not likelihood, that most if not all bunyaviruses currently recognized may represent reassortants, some of which may be reassortants of existing viruses, and some of which may be reassortants of extinct viruses. If this hypothesis is correct, then the roots of the family and genus trees of bunyaviruses as currently described (or ignored) are incomplete or incorrect. en_US
dc.language.iso en_US en_US
dc.relation.uri en_US
dc.subject Bunyaviridae en_US
dc.subject Bunyaviruses en_US
dc.subject Genome segment reassortment en_US
dc.subject Tripartite genome en_US
dc.subject Phylogenetics en_US
dc.title Viruses of the family Bunyaviridae: are all available isolates reassortants? en_US
dc.type Article (author version) en_US 2013 en_US
dc.citation.doi doi:10.1016/j.virol.2013.07.030 en_US
dc.citation.epage 216 en_US
dc.citation.issue 1-2 en_US
dc.citation.jtitle Virology en_US
dc.citation.spage 207 en_US
dc.citation.volume 446 en_US
dc.contributor.authoreid shiggs en_US

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