Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors

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dc.contributor.author Prior, Allan M.
dc.contributor.author Kim, Yunjeong
dc.contributor.author Weerasekara, Sahani
dc.contributor.author Moroze, Meghan
dc.contributor.author Alliston, Kevin R.
dc.contributor.author Uy, Roxanne Adeline Z.
dc.contributor.author Groutas, William C.
dc.contributor.author Chang, Kyeong-Ok
dc.contributor.author Hua, Duy H.
dc.date.accessioned 2014-02-21T22:35:30Z
dc.date.available 2014-02-21T22:35:30Z
dc.date.issued 2013-12-01
dc.identifier.uri http://hdl.handle.net/2097/17181
dc.description.abstract A class of tripeptidyl transition state inhibitors containing a P1 glutamine surrogate, a P2 leucine, and a P3 arylalanines, was found to potently inhibit Norwalk virus replication in enzyme and cell based assays. An array of warheads, including aldehyde, α-ketoamide, bisulfite adduct, and α-hydroxyphosphonate transition state mimic, was also investigated. Tripeptidyls 2 and 6 possess antiviral activities against noroviruses, human rhinovirus, severe acute respiratory syndrome coronavirus, and coronavirus 229E, suggesting a broad range of antiviral activities. en_US
dc.language.iso en_US en_US
dc.relation.uri http://doi.org/10.1016/j.bmcl.2013.09.070 en_US
dc.rights This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.rights.uri http://rightsstatements.org/vocab/InC/1.0/
dc.subject Viral 3C and 3C-like protease inhibitors en_US
dc.subject Norovirus en_US
dc.subject Human rhinovirus en_US
dc.subject Severe acute respiratory syndrome coronavirus en_US
dc.subject Conronavirus 229E en_US
dc.title Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors en_US
dc.type Article (author version) en_US
dc.date.published 2013 en_US
dc.citation.doi 10.1016/j.bmcl.2013.09.070 en_US
dc.citation.epage 6320 en_US
dc.citation.issue 23 en_US
dc.citation.jtitle Bioorganic & Medicinal Chemistry Letters en_US
dc.citation.spage 6317 en_US
dc.citation.volume 23 en_US
dc.contributor.authoreid ykim en_US
dc.contributor.authoreid kchang en_US
dc.contributor.authoreid duy en_US
dc.contributor.authoreid sahaniw


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This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). Except where otherwise noted, the use of this item is bound by the following: This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).

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