Humoral innate immune response and disease

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dc.contributor.author Shishido, Stephanie N.
dc.contributor.author Varahan, Sriram
dc.contributor.author Yuan, Kai
dc.contributor.author Li, Xiangdong
dc.contributor.author Fleming, Sherry D.
dc.date.accessioned 2013-10-16T15:42:07Z
dc.date.available 2013-10-16T15:42:07Z
dc.date.issued 2013-10-16
dc.identifier.uri http://hdl.handle.net/2097/16670
dc.description.abstract The humoral innate immune response consists of multiple components, including the naturally occurring antibodies (NAb), pentraxins and the complement and contact cascades. As soluble, plasma components, these innate proteins provide key elements in the prevention and control of disease. However, pathogens and cells with altered self proteins utilize multiple humoral components to evade destruction and promote pathogy. Many studies have examined the relationship between humoral immunity and autoimmune disorders. This review focuses on the interactions between the humoral components and their role in promoting the pathogenesis of bacterial and viral infections and chronic diseases such as atherosclerosis and cancer. Understanding the beneficial and detrimental aspects of the individual components and the interactions between proteins which regulate the innate and adaptive response will provide therapeutic targets for subsequent studies. en_US
dc.language.iso en_US en_US
dc.relation.uri http://www.sciencedirect.com/science/article/pii/S1521661612001568 en_US
dc.subject Complement en_US
dc.subject Contact cascade en_US
dc.subject Pentraxins en_US
dc.subject Natural antibodies en_US
dc.subject Cancer en_US
dc.subject Infection en_US
dc.title Humoral innate immune response and disease en_US
dc.type Article (author version) en_US
dc.date.published 2012 en_US
dc.citation.doi doi:10.1016/j.clim.2012.06.002 en_US
dc.citation.epage 158 en_US
dc.citation.issue 2 en_US
dc.citation.jtitle Clinical Immunology en_US
dc.citation.spage 142 en_US
dc.citation.volume 144 en_US
dc.contributor.authoreid sdflemin en_US


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