Grape exosome-like nanoparticles, a novel inducer of intestinal stem cells, protect mice against DSS induced colitis

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dc.contributor.author Ju, Songwen
dc.contributor.author Mu, Jingyao
dc.contributor.author Dokland, Terje
dc.contributor.author Zhuang, Xiaoying
dc.contributor.author Wang, Qilong
dc.contributor.author Jiang, Hong
dc.contributor.author Xiang, Xiaoyu
dc.contributor.author Deng, Zhong-Bin
dc.contributor.author Wang, Baomei
dc.contributor.author Zhang, Lifeng
dc.contributor.author Roth, Mary R.
dc.contributor.author Welti, Ruth
dc.contributor.author Mobley, James
dc.contributor.author Jun, Yan
dc.contributor.author Miller, Donald
dc.contributor.author Zhang, Huang-Ge
dc.date.accessioned 2013-08-26T19:24:59Z
dc.date.available 2013-08-26T19:24:59Z
dc.date.issued 2013-08-26
dc.identifier.uri http://hdl.handle.net/2097/16363
dc.description.abstract Food derived exosome-like nanoparticles pass through the intestinal tract throughout our lives, but little is known about their impact or function. Here, as a proof of concept, we show that the cells targeted by grape exosome-like nanoparticles (GELNs) are intestinal stem cells whose responses underlie the GELN-mediated intestinal tissue remodeling and protection against dextran sulfate sodium (DSS) induced colitis. This finding is further supported by the fact that co-culturing of crypt or sorted Lgr5+ stem cells with GELNs markedly improved organoid formation. GELN lipids play a role in induction of Lgr5+ stem cells, and the liposome-like nanoparticles (LLNs) assembled with lipids from GELNs are required for in vivo targeting of intestinal stem cells. Blocking β-catenin mediated signaling pathways of GELN recipient cells attenuates the production of Lgr5+ stem cells. Thus, GELNs not only modulate intestinal tissue renewal processes, but can participate in the remodeling of it in response to pathological triggers. en_US
dc.language.iso en_US en_US
dc.relation.uri http://www.nature.com/mt/journal/v21/n7/full/mt201364a.html en_US
dc.subject Grape exosome-like nanoparticles en_US
dc.subject Exosomes en_US
dc.subject Lipids en_US
dc.subject Intestinal stem cell en_US
dc.subject Wnt/β-catenin pathway en_US
dc.title Grape exosome-like nanoparticles, a novel inducer of intestinal stem cells, protect mice against DSS induced colitis en_US
dc.title.alternative Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis en_US
dc.type Article (author version) en_US
dc.date.published 2013 en_US
dc.citation.doi doi:10.1038/mt.2013.64 en_US
dc.citation.epage 1357 en_US
dc.citation.issue 7 en_US
dc.citation.jtitle Molecular Therapy en_US
dc.citation.spage 1345 en_US
dc.citation.volume 21 en_US
dc.contributor.authoreid mrroth en_US
dc.contributor.authoreid welti en_US


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