Nanoscopic surfactant behavior of the porin MspA in aqueous media

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dc.contributor.author Perera, Ayomi S.
dc.contributor.author Wang, Hongwang
dc.contributor.author Shrestha, Tej Bahadur
dc.contributor.author Troyer, Deryl L.
dc.contributor.author Bossmann, Stefan H.
dc.date.accessioned 2013-08-09T18:24:58Z
dc.date.available 2013-08-09T18:24:58Z
dc.date.issued 2013-04-25
dc.identifier.uri http://hdl.handle.net/2097/16212
dc.description.abstract The mycobacterial porin MspA is one of the most stable channel proteins known to date. MspA forms vesicles at low concentrations in aqueous buffers. Evidence from dynamic light scattering, transmission electron microscopy and zeta-potential measurements by electrophoretic light scattering indicate that MspA behaves like a nanoscale surfactant. The extreme thermostability of MspA allows these investigations to be carried out at temperatures as high as 343 K, at which most other proteins would quickly denature. The principles of vesicle formation of MspA as a function of temperature and the underlying thermodynamic factors are discussed here. The results obtained provide crucial evidence in support of the hypothesis that, during vesicle formation, nanoscopic surfactant molecules, such as MspA, deviate from the principles underlined in classical surface chemistry. en_US
dc.language.iso en_US en_US
dc.relation.uri http://doi.org/10.3762/bjnano.4.30 en_US
dc.rights This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.rights.uri https://rightsstatements.org/page/InC/1.0/
dc.subject Charge-interaction en_US
dc.subject Hydrophobic interaction en_US
dc.subject Liposome-type cluster en_US
dc.subject Protein cluster en_US
dc.subject Temperature influence en_US
dc.subject Zeta potential en_US
dc.title Nanoscopic surfactant behavior of the porin MspA in aqueous media en_US
dc.type Article (publisher version) en_US
dc.date.published 2013 en_US
dc.citation.doi 10.3762/bjnano.4.30 en_US
dc.citation.epage 284 en_US
dc.citation.jtitle Beilstein Journal of Nanotechnology en_US
dc.citation.spage 278 en_US
dc.citation.volume 4 en_US
dc.contributor.authoreid hongwang en_US
dc.contributor.authoreid tbs3 en_US
dc.contributor.authoreid troyer en_US
dc.contributor.authoreid sbossman en_US


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This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). Except where otherwise noted, the use of this item is bound by the following: This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).

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