Analyses of pig genomes provide insight into porcine demography and evolution

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dc.contributor.author Groenen, Martien A. M.
dc.contributor.author Archibald, Alan L.
dc.contributor.author Uenishi, Hirohide
dc.contributor.author Tuggle, Christopher K.
dc.contributor.author Takeuchi, Yasuhiro
dc.contributor.author Rothschild, Max F.
dc.contributor.author Rogel-Gaillard, Claire
dc.contributor.author Blecha, Frank
dc.contributor.author Sang, Yongming
dc.date.accessioned 2013-05-22T20:52:51Z
dc.date.available 2013-05-22T20:52:51Z
dc.date.issued 2013-05-22
dc.identifier.uri http://hdl.handle.net/2097/15848
dc.description.abstract For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars ~1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model. en_US
dc.language.iso en_US en_US
dc.relation.uri http://www.nature.com/nature/journal/v491/n7424/full/nature11622.html en_US
dc.subject Pig genomes en_US
dc.subject Duroc pig en_US
dc.subject Sus scrofa en_US
dc.subject Porcine demography en_US
dc.subject Porcine evolution en_US
dc.title Analyses of pig genomes provide insight into porcine demography and evolution en_US
dc.type Article (publisher version) en_US
dc.date.published 2012 en_US
dc.citation.doi doi:10.1038/nature11622 en_US
dc.citation.epage 398 en_US
dc.citation.issue 7424 en_US
dc.citation.jtitle Nature en_US
dc.citation.spage 393 en_US
dc.citation.volume 491 en_US
dc.contributor.authoreid blecha en_US
dc.contributor.authoreid ysang en_US


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