Live attenuated influenza vaccine provides superior protection from heterologous infection in pigs with maternal antibodies without inducing vaccine associated enhanced respiratory disease

K-REx Repository

Show simple item record

dc.contributor.author Vincent, Amy L.
dc.contributor.author Ma, Wenjun
dc.contributor.author Lager, Kelly M.
dc.contributor.author Richt, Juergen A.
dc.contributor.author Janke, Bruce H.
dc.contributor.author Sandbulte, Matthew R.
dc.contributor.author Gauger, Philip
dc.contributor.author Loving, Crystal L.
dc.contributor.author Webby, Richard J.
dc.contributor.author García-Sastre, Adolfo
dc.date.accessioned 2013-03-05T17:30:54Z
dc.date.available 2013-03-05T17:30:54Z
dc.date.issued 2013-03-05
dc.identifier.uri http://hdl.handle.net/2097/15338
dc.description.abstract Control of swine influenza A virus (IAV) in the US is hindered since inactivated vaccines do not provide robust cross‐protection against the multiple antigenic variants co‐circulating in the field. Vaccine efficacy can be further limited when administered to young pigs that possess maternally derived immunity. We previously demonstrated a recombinant A/sw/Texas/4199‐2/1998 (TX98) (H3N2) expressing a truncated NS1 protein is attenuated in swine and has potential for use as an intranasal live attenuated influenza virus (LAIV) vaccine. In the present study, we compared 1 dose of intranasal LAIV with 2 intramuscular doses of TX98 whole inactivated virus (WIV) with adjuvant in weanling pigs with and without TX98‐specific maternally‐derived antibodies (MDA). Pigs were subsequently challenged with wild type homologous TX98 H3N2 virus or with an antigenic variant A/sw/Colorado/23619/1999 (CO99) (H3N2). In the absence of MDA, both vaccines protected against homologous TX98 and heterologous CO99 shedding, although the LAIV elicited lower hemagglutination inhibiting (HI) antibody titers in serum. The efficacy of both vaccines was reduced by the presence of MDA; however, WIV vaccination of MDA‐positive pigs led to dramatically enhanced pneumonia following heterologous challenge, a phenomenon known as vaccine‐associated enhanced respiratory disease (VAERD). A single‐dose of LAIV to MDA‐positive pigs still provided partial protection from CO99 and may be a safer vaccine for young pigs in field conditions where dams are routinely vaccinated and diverse IAV strains are in circulation. These results have implications not only to pigs but to other influenza virus host species. en_US
dc.language.iso en_US en_US
dc.relation.uri http://jvi.asm.org/content/86/19/10597.abstract en_US
dc.subject Swine influenza A virus en_US
dc.subject Influenza en_US
dc.subject Vaccine efficacy en_US
dc.title Live attenuated influenza vaccine provides superior protection from heterologous infection in pigs with maternal antibodies without inducing vaccine associated enhanced respiratory disease en_US
dc.type Article (author version) en_US
dc.date.published 2012 en_US
dc.citation.doi doi:10.1128/JVI.01439-12 en_US
dc.citation.epage 10605 en_US
dc.citation.issue 19 en_US
dc.citation.jtitle Journal of Virology en_US
dc.citation.spage 10597 en_US
dc.citation.volume 86 en_US
dc.contributor.authoreid jricht en_US
dc.contributor.authoreid wjma en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search K-REx


Advanced Search

Browse

My Account

Statistics








Center for the

Advancement of Digital

Scholarship

118 Hale Library

Manhattan KS 66506


(785) 532-7444

cads@k-state.edu