Pharmacokinetics of intramuscular morphine in the horse

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dc.contributor.author Devine, Elizabeth P
dc.date.accessioned 2012-05-24T17:15:43Z
dc.date.available 2012-05-24T17:15:43Z
dc.date.issued 2012-05-24
dc.identifier.uri http://hdl.handle.net/2097/13864
dc.description.abstract Pharmacokinetics of Intramuscular Morphine in the Horse Elizabeth Devine, DVM; Butch KuKanich, DVM, PhD, DACVCP; Warren Beard, DVM, MS, DACVS Objective - To determine the pharmacokinetics of morphine after intramuscular administration in a clinical population of horses Design – Prospective, clinical study Animals – Pilot study included 2 normal horses and the clinical study included 75 horses Procedures – Morphine was administered at 0.1mg/kg, IM and 2-3 blood samples were obtained from each horse at various times from 0-9 hours after administration. Plasma morphine concentrations were measured using liquid chromatography and mass spectrometry. Results – Data was analyzed using a naïve pooled pharmacokinetic model. The half-life for the elimination phase was approximately 1.5 hours, the volume of distribution (per bioavailability) was approximately 4.5 L/kg and the clearance (per bioavailability) was approximately 35 mL/kg/min. The peak plasma concentration was 21.6 ng/mL and occurred approximately 4 minutes after administration. Plasma concentrations of morphine were below the limit of quantification by 7 hours in 74 horses. Conclusions and Clinical Relevance – The relatively short half-life of morphine indicates the need for frequent dosing to maintain targeted plasma concentrations. Adverse effects were uncommon in this study and morphine was well tolerated at a dose of 0.1 mg/kg, IM. Morphine may be a useful adjunctive therapy in painful horses, but the variable plasma concentrations suggest the dose and dosing interval may need to be adjusted to the individual patient’s response. en_US
dc.description.sponsorship Department of Clinical Sciences Research Funding Committee and the Analytical Pharmacology Laboratory at Kansas State University en_US
dc.language.iso en_US en_US
dc.publisher Kansas State University en
dc.subject Morphine en_US
dc.subject Pharmacokinetics en_US
dc.subject Equine en_US
dc.title Pharmacokinetics of intramuscular morphine in the horse en_US
dc.type Report en_US
dc.description.degree Master of Science en_US
dc.description.level Masters en_US
dc.description.department Department of Clinical Sciences en_US
dc.description.advisor Warren L. Beard en_US
dc.subject.umi Veterinary Medicine (0778) en_US
dc.date.published 2012 en_US
dc.date.graduationmonth August en_US


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