Exploring physical properties of nanoparticles for biomedical applications

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dc.contributor.author Dani, Raj Kumar
dc.date.accessioned 2012-05-01T13:22:42Z
dc.date.available 2012-05-01T13:22:42Z
dc.date.issued 2012-05-01
dc.identifier.uri http://hdl.handle.net/2097/13773
dc.description.abstract The research work in this thesis aims at investigating the basic physic-chemical properties of magnetic and metal nanoparticles (NPs) for biomedical applications such as magnetic hyperthermia and controlled drug release. Magneto-plasmonic properties of magnetic NPs are important to evaluate potential applications of these materials. Magnetic property can be used to control, monitor and deliver the particles using a magnetic field while plasmonic property allows the tracking of the position of the particles, but aggregation of NPs could pose a problem. Here, the aggregation of NPs is investigated via the Faraday rotation of gold coated Fe[subscript]2O[subscript]3 NPs in alternating magnetic fields. In addition, the Faraday rotation of the particles is measured in pulsed magnetic fields, which can generate stronger magnetic fields than traditional inductive heaters used in the previous experiments. In the second project, the formation of protein-NPs complexes is investigated for hyperthermia treatment. The interactions between gold and iron-platinum NPs with octameric mycobacterial porin A from Mycobacterium smegmatis (MspA) and MspA[superscript])cys protein molecules are examined to assemble a stable, geometrically suitable and amphiphilic proteins-NPs complex. Magnetic NPs show promising heating effects in magnetic hyperthermia to eliminate cancer cells selectively in the presence of alternating magnetic field. As a part of investigation, the heating capacity of a variety of magnetic NPs and the effects of solvent viscosity are investigated to obtain insight into the heating mechanism of these particles. Finally, the controlled drug release of magnetic NPs loaded liposomes by pulsed magnetic field is investigated. The preliminary data indicate about 5-10% release of drug after the application of 2 Tesla magnetic pulses. The preliminary experiments will serve as the initial stage of investigation for more effective magnetic hyperthermia treatment with the help of short magnetic pulses. en_US
dc.language.iso en_US en_US
dc.publisher Kansas State University en
dc.subject Magnetic hyperthermia en_US
dc.subject Drug release en_US
dc.subject Faraday Rotation en_US
dc.subject Magnetic nanoparticles en_US
dc.subject Cancer treatment en_US
dc.subject Magnetoliposomes en_US
dc.title Exploring physical properties of nanoparticles for biomedical applications en_US
dc.type Dissertation en_US
dc.description.degree Doctor of Philosophy en_US
dc.description.level Doctoral en_US
dc.description.department Department of Chemistry en_US
dc.description.advisor Viktor Chikan en_US
dc.subject.umi Chemistry (0485) en_US
dc.subject.umi Oncology (0992) en_US
dc.subject.umi Physical Chemistry (0494) en_US
dc.date.published 2012 en_US
dc.date.graduationmonth May en_US

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