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Browsing Chemistry Faculty Research and Publications by Author

Browsing Chemistry Faculty Research and Publications by Author "Desper, John"

Now showing items 1-13 of 13

Altering physical properties of pharmaceutical co-crystals in a systematic manner

Aakeröy, Christer B.; Forbes, Safiyyah; Desper, John (2014-08-15)

Systematic structure-property studies on a series of co-crystals of potential cancer drugs with aliphatic dicarboxylic acids were undertaken. This study reveals that systematic changes to the molecular nature of the ...
Competing hydrogen-bond and halogen-bond donors in crystal engineering

Aakeröy, Christer B.; Panikkattu, Sheelu; Chopade, Prashant D.; Desper, John (2013-02-18)

In order to study the structure-directing competition between hydrogen- and alogen-bond donors we have synthesized two ligands, 3,3’-azobipyridine and 4,4’-azobipyridine, and co-crystallized them with a series of bi-functional ...
Competing hydrogen-bond donors: phenols vs. cyanooximes

Aakeröy, Christer B.; Epa, Kanishka N.; Forbes, Safiyyah; Desper, John (2013-09-10)

Based on a systematic structural study of co-crystals of a ditopic probe molecule, (Z)-N,4-dihydroxybenzimidoyl cyanide, decorated with an –OH group and a cyanooxime moiety, it has been shown that in a competitive molecular ...
Constructing molecular polygons using halogen bonding and bifurcated N-oxides

Aakeröy, Christer B.; Wijethunga, Tharanga K.; Desper, John (2014-01-22)

Bifurcated halogen bonds constructed from N-oxides and complementary halogen-bond donors provide the basis for a synthetic strategy for the deliberate assembly of molecular polygons in the solid state. The donor- and ...
Interdependence of structure and physical properties in co-crystals of azopyridines

Aakeröy, Christer B.; Panikkattu, Sheelu; DeHaven, Baillie; Desper, John (2013-07-16)

To establish how intermolecular interactions influence the supramolecular assembly of azopyridines, a total of five co-crystals of 3,3′ and 4,4′-azopyridine; 3,3′-azpy:succinic acid (3,3′-azpy:SA), 3,3′-azpy:adipic acid ...
The quest for a molecular capsule assembled via halogen bonds

Aakeröy, Christer B.; Rajbanshi, Arbin; Metrangolo, Pierangelo; Resnati, Giuseppe; Parisi, Melchiorre F.; Desper, John; Pilati, Tullio (2012-11-08)

A halogen-bonded capsule is obtained via directed assembly of a rigid tetra(3-pyridyl) cavitand and a flexible tetra(4-iodotetrafluorophenyl) calix[4]arene. The pyridyl nitrogen atoms from one cavitand molecule interact ...
Silver (I) coordination chemistry: from 1-D chains to molecular rectangles

Abul-Haj, Mohammad; Aakeröy, Christer B.; Desper, John (2013-02-15)

A series of silver(I) coordination compounds with the ligand 2-(4-pyridyl)imidazole 4-PyIm has been synthesized and crystallographically characterized in order to explore the role of counter ion, solvent and ligand charge ...
Structural chemistry of oximes

Aakeröy, Christer B.; Sinha, Abhijeet Shekhar; Epa, Kanishka N.; Chopade, Prashant D.; Smith, Michelle M.; Desper, John (2013-07-30)

Oximes (RR'C=N-OH) represent an important class of organic compounds with a wide range of practical applications, but a systematic examination of the structural chemistry of such compounds has so far not been carried out. ...
Structure and thermodynamics of a multimeric cavitand assembly

Aakeröy, Christer B.; Chopade, Prashant D.; Quinn, Colette F.; Desper, John (2014-06-20)

A set of COOH···N(pyridine) 5 hydrogen bonds have been utilized in the targeted synthesis of a cavitand-based assembly. A cavitand appended with four pyridyl groups was synthesized from a Suzuki coupling of a tetrabromocavitand ...
Syntheses of 3-[(Alkylamino)methylene]-6-methyl-1Hpyridine-2,4-diones, Fluorescence Probes 3-Substituted 7-Methyl-6H-pyrano[3,2-c]pyridine-2,5-diones, and Tetrahydro-6H-2,10-dioxa-9-azaanthracen-1-ones

Prior, Allan M.; Gunaratna, Medha J.; Kikuchi, Daisuke; Desper, John; Kim, Yunjeong; Chang, Kyeong-ok; Maezawa, Izumi; Jin, Lee-Way; Hua, Duy H. (2014-11-14)

Various condensation and ring-closing reactions were used for the syntheses of 3-[(alkylamino)methylene]-6-methylpyridine-2,4(1H,3H)-diones, bicyclic pyridinones, and tricyclic morpholinopyrones. For instance, 3-[(dialky ...
Synthesis and antiviral activity of substituted quercetins

Thapa, Mahendra; Kim, Yunjeong; Desper, John; Chang, Kyeong-Ok; Hua, Duy H. (2012-05-21)

Influenza viruses are important pathogens that cause respiratory infections in humans and animals. In addition to vaccination, antiviral drugs against influenza virus play a significant role in controlling viral infections ...
Synthesis and characterization of TiL2 complexes with tridentate (ONO) (S)-NOBIN Schiff-base ligands

Barman, Sanmitra; Desper, John; Levy, Christopher J. (2015-05-08)

Tridentate (ONO) C[subscript 1]-symmetric Schiff base ligands were synthesized by the condensation of (S)-2-amino-2'-hydroxy-1,1'-binaphthyalene with 4-hydroxy-3-phenanthrenecarboxaldehyde or 1-hydroxybenz[a]anthracene-2 ...
A versatile and green mechanochemical route for aldehyde-oxime conversions

Aakeröy, Christer B.; Sinha, Abhijeet Shekhar; Epa, Kanishka N.; Spartz, Christine L.; Desper, John (2012-11-26)

A robust, facile and solvent-free mechanochemical path for aldehyde–oxime transformations using hydroxylamine and NaOH is explored; the method is suitable for aromatic and aliphatic aldehydes decorated with a range of ...