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Cell Based Drug Delivery: Micrococcus luteus Loaded Neutrophils as Chlorhexidine Delivery Vehicles in a Mouse Model of Liver Abscesses in Cattle

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dc.citation.doi10.1371/journal.pone.0128144
dc.citation.issn1932-6203
dc.citation.issue5
dc.citation.jtitlePLoS One
dc.citation.spage13
dc.citation.volume10
dc.contributor.authorWendel, S. O.
dc.contributor.authorMenon, S.
dc.contributor.authorAlshetaiwi, H.
dc.contributor.authorShrestha, Tej Bahadur
dc.contributor.authorChlebanowski, L.
dc.contributor.authorHsu, Wei-Wen
dc.contributor.authorBossmann, Stefan H.
dc.contributor.authorNarayanan, Sanjeev K.
dc.contributor.authorTroyer, Deryl L.
dc.contributor.authoreidwwhsu
dc.contributor.authoreidsbossman
dc.contributor.authoreidsnarayan
dc.contributor.authoreidtroyer
dc.date.accessioned2016-04-06T15:21:27Z
dc.date.available2016-04-06T15:21:27Z
dc.date.published2015
dc.descriptionCitation: Wendel, S. O., Menon, S., Alshetaiwi, H., Shrestha, T. B., Chlebanowski, L., Hsu, W. W., . . . Troyer, D. L. (2015). Cell Based Drug Delivery: Micrococcus luteus Loaded Neutrophils as Chlorhexidine Delivery Vehicles in a Mouse Model of Liver Abscesses in Cattle. Plos One, 10(5), 13. doi:10.1371/journal.pone.0128144
dc.descriptionThe recent WHO report on antibiotic resistances shows a dramatic increase of microbial resistance against antibiotics. With only a few new antibiotics in the pipeline, a different drug delivery approach is urgently needed. We have obtained evidence demonstrating the effectiveness of a cell based drug delivery system that utilizes the innate immune system as targeting carrier for antibacterial drugs. In this study we show the efficient loading of neutrophil granulocytes with chlorhexidine and the complete killing of E. coli as well as Fusobacterium necrophorum in in-vitro studies. Fusobacterium necrophorum causes hepatic abscesses in cattle fed high grain diets. We also show in a mouse model that this delivery system targets infections of F. necrophorum in the liver and reduces the bacterial burden by an order of magnitude from approximately 2.10(6) to 1.10(5).
dc.identifier.urihttp://hdl.handle.net/2097/32477
dc.relation.urihttps://doi.org/10.1371/journal.pone.0128144
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectFusobacterium-Necrophorum Leukotoxin
dc.subjectFeedlot Cattle
dc.subjectResistance
dc.subjectAntiseptics
dc.subjectBacteria
dc.subjectScience & Technology - Other Topics
dc.titleCell Based Drug Delivery: Micrococcus luteus Loaded Neutrophils as Chlorhexidine Delivery Vehicles in a Mouse Model of Liver Abscesses in Cattle
dc.typeArticle

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