Differential expression of type I interferons in fetal tissues and the maternal-fetal interface in response to PRRSV infection
| dc.contributor.author | Sang, Wenjing | |
| dc.date.accessioned | 2012-08-10T19:55:48Z | |
| dc.date.available | 2012-08-10T19:55:48Z | |
| dc.date.graduationmonth | August | en_US |
| dc.date.issued | 2012-08-10 | |
| dc.date.published | 2012 | en_US |
| dc.description.abstract | Interferons (IFNs) comprise a group of antiviral cytokines; however, their expression at the porcine maternal-fetal interface and in fetal tissues has not previously been investigated. The purpose of this study was to analyze the expression of type I IFNs and their receptors in maternal and fetal tissues from sows infected with PRRSV. The approach was to use real-time RT-PCR to identify the expression of different subtypes of type I IFN genes. The results show that the constitutive gene expression of some subtypes including IFN-[alpha] and IFN-[alpha][omega] were detected in fetal lymphoid nodes (IFN-[alpha][omega]), placenta (several IFN-[alpha] subtypes and IFN-[omega]5) and particularly, thymus (multiple IFN-[alpha], IFN-[delta] and IFN-[omega]5). The results demonstrate that porcine type I IFNs are differentially expressed at the maternal-fetal interface and in fetal tissues in response to PRRSV infection. | en_US |
| dc.description.advisor | Raymond R. R. Rowland | en_US |
| dc.description.degree | Master of Science | en_US |
| dc.description.department | Department of Diagnostic Medicine/Pathobiology | en_US |
| dc.description.level | Masters | en_US |
| dc.identifier.uri | http://hdl.handle.net/2097/14183 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Kansas State University | en |
| dc.subject | PRRSV | en_US |
| dc.subject | Type I IFN expression | en_US |
| dc.subject.umi | Biomedical Engineering (0541) | en_US |
| dc.title | Differential expression of type I interferons in fetal tissues and the maternal-fetal interface in response to PRRSV infection | en_US |
| dc.type | Thesis | en_US |
