Expansion of human mesenchymal stem cells in a fixed-bed bioreactor system based on non-porous glass carrier – Part B: Modeling and scale-up of the system

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dc.contributor.author Weber, Christian
dc.contributor.author Freimark, Denise
dc.contributor.author Portner, Ralf
dc.contributor.author Pino-Grace, Pablo
dc.contributor.author Pohl, Sebastian
dc.contributor.author Wallrapp, Christine
dc.contributor.author Geigle, Peter
dc.contributor.author Czermak, Peter
dc.date.accessioned 2011-04-21T15:15:36Z
dc.date.available 2011-04-21T15:15:36Z
dc.date.issued 2011-04-21
dc.identifier.uri http://hdl.handle.net/2097/8441
dc.description.abstract Human mesenchymal stem cells (hMSC) are a promising cell source for the manufacturing of cell therapeutic or tissue engineered implants. In part A of this publication a fixed-bed bioreactor system based on non-porous borosilicate glass spheres and procedures for the automated expansion of hMSC with high yield and vitality has been introduced. Part B of this study deals with the modeling of the process in order to transfer the bioreactors system from the laboratory to the production scale. Relevant model parameters have been obtained by fitting them to the experimental data of hMSC-TERT cultivations in scales up to 300 cm3. Scale-up calculations were carried out exemplarily for a target cell number of twenty billion cells. en_US
dc.publisher Wichtig Editore en_US
dc.relation.uri http://www.artificial-organs.com/public/IJAO/Issue/Issue.aspx?UidIssue=6075300D-381E-4BE5-98FC-22498D389E15 en_US
dc.subject Mesenchymal stem cells en_US
dc.subject hMSC-TERT en_US
dc.subject Fixed-bed bioreactor en_US
dc.subject Glass carrier en_US
dc.subject Scale up en_US
dc.title Expansion of human mesenchymal stem cells in a fixed-bed bioreactor system based on non-porous glass carrier – Part B: Modeling and scale-up of the system en_US
dc.type Article (author version) en_US
dc.date.published 2010 en_US
dc.citation.epage 795 en_US
dc.citation.issue 11 en_US
dc.citation.jtitle International Journal of Artificial Organs en_US
dc.citation.spage 782 en_US
dc.citation.volume 33 en_US
dc.contributor.authoreid pczermak en_US

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