Serum Metabolomic Profiling of Piglets Infected with Virulent Classical Swine Fever Virus

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dc.contributor.author Gong, Wenjie J.
dc.contributor.author Jia, J. J.
dc.contributor.author Zhang, B. K.
dc.contributor.author Mi, S. J.
dc.contributor.author Zhang, L.
dc.contributor.author Xie, X. M.
dc.contributor.author Guo, H. C.
dc.contributor.author Shi, Jishu
dc.contributor.author Tu, C. C.
dc.date.accessioned 2017-11-30T21:38:31Z
dc.date.available 2017-11-30T21:38:31Z
dc.identifier.uri http://hdl.handle.net/2097/38285
dc.description Citation: Gong, W. J., Jia, J. J., Zhang, B. K., Mi, S. J., Zhang, L., Xie, X. M., . . . Tu, C. C. (2017). Serum Metabolomic Profiling of Piglets Infected with Virulent Classical Swine Fever Virus. Frontiers in Microbiology, 8, 14. doi:10.3389/fmicb.2017.00731
dc.description.abstract Classical swine fever (CSF) is a highly contagious swine infectious disease and causes significant economic losses for the pig industry worldwide. The objective of this study was to determine whether small molecule metabolites contribute to the pathogenesis of CSF. Birefly, serum metabolomics of CSFV Shimen strain-infected piglets were analyzed by ultraperformance liquid chromatography/electrospray ionization time-of-flight mass spectrometry (UPLC/ESI-Q-TOF/MS) in combination with multivariate statistical analysis. In CSFV-infected piglets at days 3 and 7 post-infection changes were found in metabolites associated with several key metabolic pathways, including tryptophan catabolism and the kynurenine pathway, phenylalanine metabolism, fatty acid and lipid metabolism, the tricarboxylic acid and urea cycles, branched-chain amino acid metabolism, and nucleotide metabolism. Several pathways involved in energy metabolism including fatty acid biosynthesis and beta-oxidation, branched-chain amino acid metabolism, and the tricarboxylic acid cycle were significantly inhibited. Changes were also observed in several metabolites exclusively associated with gut microbiota. The metabolomic profiles indicate that CSFV-host gut microbiome interactions play a role in the development of CSF.
dc.relation.uri https://doi.org/10.3389/fmicb.2017.00731
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Metabolomic Profiling
dc.subject Uplc-Ms
dc.subject Csfv
dc.subject Metabolite
dc.subject Hepatitis-C Virus
dc.subject Fatty-Acid Synthase
dc.title Serum Metabolomic Profiling of Piglets Infected with Virulent Classical Swine Fever Virus
dc.type Article
dc.date.published 2017
dc.citation.doi 10.3389/fmicb.2017.00731
dc.citation.issn 1664-302X
dc.citation.jtitle Frontiers in Microbiology
dc.citation.spage 14
dc.citation.volume 8
dc.contributor.authoreid jshi
dc.contributor.kstate Shi, Jishu


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Attribution 4.0 International (CC BY 4.0) Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)

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