Cell-based Regeneration of Intervertebral Disc Defects: Review & Concepts

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dc.contributor.author Freimark, Denise
dc.contributor.author Czermak, Peter
dc.date.accessioned 2010-04-23T21:38:06Z
dc.date.available 2010-04-23T21:38:06Z
dc.date.issued 2010-04-23T21:38:06Z
dc.identifier.uri http://hdl.handle.net/2097/3741
dc.description.abstract During the last century low back pain has been emerged as a widespread disease often caused by intervertebral disc degeneration (IDD). IDD in turn is a complex problem, in which a variety of causes play a crucial role. As IDD causes high costs, a corporate interest leads to a number of therapies developed. Today, these therapies focus on the restoration of the IVD function and not only on minimizing the pain caused by this disease. These approaches are often biological and aim to stimulate the regeneration of the intervertebral disc by injection of activator proteins, biomaterials, different cell types or complex cell-matrix-composites. Furthermore, the genetic engineering of disc cells and the in vitro tissue engineering offer a possibility for curing IDD. This article gives an overview on the concepts mentioned above. en_US
dc.subject Intervertebral disc regeneration en_US
dc.subject Cell transplantation en_US
dc.subject Mesenchymal stem cell en_US
dc.title Cell-based Regeneration of Intervertebral Disc Defects: Review & Concepts en_US
dc.type Article (author version) en_US
dc.date.published 2009 en_US
dc.citation.epage 203 en_US
dc.citation.issue 4 en_US
dc.citation.jtitle International Journal of Artificial Organs en_US
dc.citation.spage 197 en_US
dc.citation.volume 32 en_US
dc.contributor.authoreid pczermak en_US

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