Expansion of amphibian intronless interferons revises the paradigm for interferon evolution and functional diversity

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dc.contributor.author Sang, Y. M.
dc.contributor.author Liu, Qinfang
dc.contributor.author Lee, Jinhwa
dc.contributor.author Ma, Wenjun
dc.contributor.author McVey, D. Scott
dc.contributor.author Blecha, Frank
dc.date.accessioned 2017-02-14T22:47:53Z
dc.date.available 2017-02-14T22:47:53Z
dc.identifier.uri http://hdl.handle.net/2097/35114
dc.description Citation: Sang, Y. M., Liu, Q. F., Lee, J., Ma, W. J., McVey, D. S., & Blecha, F. (2016). Expansion of amphibian intronless interferons revises the paradigm for interferon evolution and functional diversity. Scientific Reports, 6, 17. doi:10.1038/srep29072
dc.description.abstract Interferons (IFNs) are key cytokines identified in vertebrates and evolutionary dominance of intronless IFN genes in amniotes is a signature event in IFN evolution. For the first time, we show that the emergence and expansion of intronless IFN genes is evident in amphibians, shown by 24-37 intronless IFN genes in each frog species. Amphibian IFNs represent a molecular complex more complicated than those in other vertebrate species, which revises the established model of IFN evolution to facilitate re-inspection of IFN molecular and functional diversity. We identified these intronless amphibian IFNs and their intron-containing progenitors, and functionally characterized constitutive and inductive expression and antimicrobial roles in infections caused by zoonotic pathogens, such as influenza viruses and Listeria monocytogenes. Amphibians, therefore, may serve as overlooked vectors/hosts for zoonotic pathogens, and the amphibian IFN system provides a model to study IFN evolution in molecular and functional diversity in coping with dramatic environmental changes during terrestrial adaption.
dc.relation.uri https://doi.org/10.1038/srep29072
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject I Interferons
dc.subject Viral-Infection
dc.subject Xenopus-Laevis
dc.subject System
dc.subject Cells
dc.subject Frog
dc.title Expansion of amphibian intronless interferons revises the paradigm for interferon evolution and functional diversity
dc.type Article
dc.date.published 2016
dc.citation.doi 10.1038/srep29072
dc.citation.issn 2045-2322
dc.citation.jtitle Scientific Reports
dc.citation.spage 17
dc.citation.volume 6
dc.contributor.authoreid ysang
dc.contributor.authoreid wjma
dc.contributor.authoreid blecha
dc.contributor.kstate Sang, Yongming
dc.contributor.kstate Ma, Wenjun
dc.contributor.kstate Blecha, Frank
dc.contributor.kstate Liu, Qinfang
dc.contributor.kstate McVey, D. Scott


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