A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles : a mouse study

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dc.contributor.author Balivada, Sivasai
dc.date.accessioned 2009-12-14T16:59:20Z
dc.date.available 2009-12-14T16:59:20Z
dc.date.issued 2009-12-14T16:59:20Z
dc.identifier.uri http://hdl.handle.net/2097/2282
dc.description.abstract There is renewed interest in magnetic hyperthermia as a treatment modality for cancer, especially when it is combined with other more traditional therapeutic approaches, such as the co-delivery of anticancer drugs or photodynamic therapy. The influence of bimagnetic nanoparticles (MNPs) combined with short external alternating magnetic field (AMF) exposure on the growth of subcutaneous mouse melanomas (B16-F10) was evaluated. Bimagnetic Fe/Fe3O4 core/shell nanoparticles were designed for cancer targeting after intratumoral or intravenous administration. Their inorganic center was protected against rapid biocorrosion by organic dopamine-oligoethylene glycol ligands. TCPP (4-tetracarboxyphenyl porphyrin) units were attached to the dopamine-oligoethylene glycol ligands. The magnetic hyperthermia results obtained after intratumoral injection indicated that micromolar concentrations of iron given within the modified core-shell Fe/Fe3O4 nanoparticles caused a significant anti-tumor effect on murine B16-F10 melanoma with three short 10-minute AMF exposures. There is a decrease in tumor size after intravenous administration of the MNPs followed by three consecutive days of AMF exposure. These results indicate that intratumoral administration of surface-modified MNPs can attenuate mouse melanoma after AMF exposure. Moreover, intravenous administration of these MNPs followed by AMF exposure attenuates melanomas, indicating that adequate amounts of TCPP-labeled stealth Fe/Fe3O4 nanoparticles can accumulate in murine melanoma after systemic delivery to allow effective magnetic hyperthermic therapy in a rodent tumor mode. en_US
dc.description.sponsorship National Institutes of Health (NIH); National Science Foundation(NSF); Small Business Innovation Research(SBIR) en_US
dc.language.iso en_US en_US
dc.publisher Kansas State University en
dc.subject Magnetic hyperthermia en_US
dc.subject Melanoma en_US
dc.subject cancer en_US
dc.subject Magnetic nanoparticles en_US
dc.title A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles : a mouse study en_US
dc.title.alternative AC magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles
dc.type Thesis en_US
dc.description.degree Master of Science en_US
dc.description.level Masters en_US
dc.description.department Department of Anatomy and Physiology en_US
dc.description.advisor Deryl L. Troyer en_US
dc.subject.umi Health Sciences, Medicine and Surgery (0564) en_US
dc.subject.umi Health Sciences, Oncology (0992) en_US
dc.date.published 2009 en_US
dc.date.graduationmonth December en_US

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