Browsing College of Engineering by Author "Freimark, Denise"

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Cell-based Regeneration of Intervertebral Disc Defects: Review & Concepts

Freimark, Denise; Czermak, Peter (2010-04-23)

During the last century low back pain has been emerged as a widespread disease often caused by intervertebral disc degeneration (IDD). IDD in turn is a complex problem, in which a variety of causes play a crucial role. As ...
Expansion of human mesenchymal stem cells in a fixed-bed bioreactor system based on non-porous glass carrier – Part A: Inoculation, cultivation, and cell harvest procedures

Weber, Christian; Freimark, Denise; Portner, Ralf; Pino-Grace, Pablo; Pohl, Sebastian; Wallrapp, Christine; Geigle, Peter; Czermak, Peter (2011-04-19)

Human mesenchymal stem cells (hMSC) are a promising cell source for several applications of regenerative medicine. The used cells are either autologous or allogenic, whereas the latter enables, especially by using of stem ...
Expansion of human mesenchymal stem cells in a fixed-bed bioreactor system based on non-porous glass carrier – Part B: Modeling and scale-up of the system

Weber, Christian; Freimark, Denise; Portner, Ralf; Pino-Grace, Pablo; Pohl, Sebastian; Wallrapp, Christine; Geigle, Peter; Czermak, Peter (Wichtig Editore, 2011-04-21)

Human mesenchymal stem cells (hMSC) are a promising cell source for the manufacturing of cell therapeutic or tissue engineered implants. In part A of this publication a fixed-bed bioreactor system based on non-porous ...
Use of encapsulated stem cells to overcome the bottleneck of cell availability for cell therapy approaches

Freimark, Denise; Pino-Grace, Pablo; Pohl, Sebastian; Weber, Christian; Wallrapp, Christine; Geigle, Peter; Portner, Ralf; Czermak, Peter (2010-04-02)

Nowadays cell-based therapy is rarely in clinical practice because of the availability of appropriate cells. To apply cells therapeutically, they may not cause any immune response wherefore up to now mainly autologous cells ...