Browsing Biology by Author "Asano, Katsura"

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Browsing Biology by Author "Asano, Katsura"

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  • Luna, Rafael E.; Arthanari, Haribabu; Hiraishi, Hiroyuki; Akabayov, Barak; Tang, Leiming; Cox, Christian; Markus, Michelle A.; Luna, Lunet E.; Ikeda, Yuka; Watanabe, Ryosuke; Bedoya, Edward; Yu, Cathy; Alikhan, Shums; Wagner, Gerhard; Asano, Katsura (2014-05-06)
    Scanning of the mRNA transcript by the preinitiation complex (PIC) requires a panel of eukaryotic initiation factors including eIF1 and eIF1A, the main transducers of stringent AUG selection. eIF1A plays an important role ...
  • Obayashi, E.; Luna, R. E.; Nagata, T.; Martin-Marcos, P.; Hiraishi, H.; Singh, Chingakham Ranjit; Erzberger, J. P.; Zhang, F.; Arthanari, H.; Morris, J.; Pellarin, R.; Moore, C.; Harmon, I.; Papadopoulos, E.; Yoshida, H.; Nasr, M. L.; Unzai, S.; Thompson, B.; Aube, E.; Hustak, S.; Stengel, F.; Dagraca, E.; Ananbandam, A.; Gao, P.; Urano, T.; Hinnebusch, A. G.; Wagner, G.; Asano, Katsura
    During eukaryotic translation initiation, eIF3 binds the solvent-accessible side of the 40S ribosome and recruits the gate-keeper protein eIF1 and eIF5 to the decoding center. This is largely mediated by the N-terminal ...
  • Gandin, V.; Masvidal, L.; Cargnello, M.; Gyenis, L.; McLaughlan, S.; Cai, Y. T.; Tenkerian, C.; Morita, M.; Balanathan, P.; Jean-Jean, O.; Stambolic, V.; Trost, M.; Furic, L.; Asano, Katsura
    Ternary complex (TC) and eIF4F complex assembly are the two major rate-limiting steps in translation initiation regulated by eIF2 alpha phosphorylation and the mTOR/4E-BP pathway, respectively. How TC and eIF4F assembly ...
  • Kozel, Caitlin; Thompson, Brytteny; Hustak, Samantha; Moore, Chelsea; Nakashima, A.; Singh, Chingakham Ranjit; Reid, Megan; Cox, Christian; Papadopoulos, E.; Luna, R. E.; Anderson, Abbey; Tagami, H.; Hiraishi, Hiroyuki; Slone, Emily A.; Yoshino, K.; Asano, Masayo; Gillaspie, Sarah; Nietfeld, Jerome; Perchellet, Jean-Pierre; Rothenburg, Stefan; Masai, H.; Wagner, G.; Beeser, Alexander; Kikkawa, U.; Fleming, Sherry D.; Asano, Katsura
    ATF4 is a pro-oncogenic transcription factor whose translation is activated by eIF2 phosphorylation through delayed re-initiation involving two uORFs in the mRNA leader. However, in yeast, the effect of eIF2 phosphorylation ...
  • Singh, Chingakham Ranjit; Watanabe, Ryosuke; Chowdhury, Wasimul Q.; Hiraishi, Hiroyuki; Murai, Marcelo J.; Yamamoto, Yasufumi; Miles, David; Ikeda, Yuka; Asano, Masayo; Asano, Katsura (2012-12-04)
    During translation initiation in Saccharomyces cerevisiae, an Arg- and Ser-rich segment (RS1 domain) of eIF4G and the Lys-rich segment (K-boxes) of eIF2β bind three common partners, eIF5, eIF1 and mRNA. Here we report that ...

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