The effect of antineoplastic drugs in a male spontaneous mammary tumor model

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Show simple item record Shishido, Stephanie N. Faulkner, Emma B. Beck, Amanda Nguyen, Thu A. 2013-07-16T19:59:50Z 2013-07-16T19:59:50Z 2013-07-16
dc.description.abstract Male breast cancer is a rare disease. The limited number of clinical cases has led to the primary treatments for men being derived from female breast cancer studies. Here the transgenic strain FVB/N-Tg(MMTV-PyVT)634Mul/J (also known as PyVT) was used as a model system for measuring tumor burden and drug sensitivity of the antineoplastic drugs tamoxifen, cisplatin, and paclitaxel on tumorigenesis at an early stage of mammary carcinoma development in a male mouse model. Cisplatin treatment significantly reduced tumor volume, while paclitaxel and tamoxifen did not attenuate tumor growth. Cisplatin treatment was shown to induce apoptosis, grossly observed by reduced tumor formation, through reduced Bcl-2 and survivin protein expression levels with an increase in caspase 3 expression compared to control tumors. Tamoxifen treatment significantly altered the hormone receptor expression levels of the tumor, while additionally upregulating Bcl-2 and Cyclin D1. This suggests an importance in hormonal signaling in male breast cancer pathogenesis. The results of this study provide valuable information toward the better understanding of male breast cancer and may help guide treatment decisions. en_US
dc.language.iso en_US en_US
dc.relation.uri en_US
dc.subject Breast cancer en_US
dc.subject Male breast cancer en_US
dc.subject Antineoplastic drugs en_US
dc.title The effect of antineoplastic drugs in a male spontaneous mammary tumor model en_US
dc.type Article (publisher version) en_US 2013 en_US
dc.citation.doi doi:10.1371/journal.pone.0064866 en_US
dc.citation.issue 6 en_US
dc.citation.jtitle PLoS ONE en_US
dc.citation.spage e64866 en_US
dc.citation.volume 8 en_US
dc.contributor.authoreid tanguyen en_US

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