Peptide nanovesicles formed by the self-assembly of branched amphiphilic peptides

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Show simple item record Gudlur, Sushanth Sukthankar, Pinakin Gao, Jian Avila, L. Adriana Hiromasa, Yasuaki Chen, Jianhan Iwamoto, Takeo Tomich, John M. 2012-11-08T19:18:25Z 2012-11-08T19:18:25Z 2012-11-08
dc.description.abstract Peptide-based packaging systems show great potential as safer drug delivery systems. They overcome problems associated with lipid-based or viral delivery systems, vis-a-vis stability, specificity, inflammation, antigenicity, and tune-ability. Here, we describe a set of 15 & 23-residue branched, amphiphilic peptides that mimic phosphoglycerides in molecular architecture. These peptides undergo supramolecular self-assembly and form solvent-filled, bilayer delimited spheres with 50–200 nm diameters as confirmed by TEM, STEM and DLS. Whereas weak hydrophobic forces drive and sustain lipid bilayer assemblies, these all-peptide structures are stabilized potentially by both hydrophobic interactions and hydrogen bonds and remain intact at low micromolar concentrations and higher temperatures. A linear peptide lacking the branch point showed no self-assembly properties. We have observed that these peptide vesicles can trap fluorescent dye molecules within their interior and are taken up by N/N 1003A rabbit lens epithelial cells grown in culture. These assemblies are thus potential drug delivery systems that can overcome some of the key limitations of the current packaging systems. en_US
dc.language.iso en_US en_US
dc.relation.uri en_US
dc.subject Peptide-based packaging systems en_US
dc.subject Drug delivery systems en_US
dc.subject Nanovesicles en_US
dc.title Peptide nanovesicles formed by the self-assembly of branched amphiphilic peptides en_US
dc.type Article (publisher version) en_US 2012 en_US
dc.citation.doi doi:10.1371/journal.pone.0045374 en_US
dc.citation.epage e45374 en_US
dc.citation.issue 9 en_US
dc.citation.jtitle PLoS ONE en_US
dc.citation.spage e45374 en_US
dc.citation.volume 7 en_US
dc.contributor.authoreid sushanth en_US
dc.contributor.authoreid pinakin en_US
dc.contributor.authoreid luzavila en_US
dc.contributor.authoreid hiromasa en_US
dc.contributor.authoreid jianhanc en_US
dc.contributor.authoreid jtomich en_US

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