Onset and duration of transient infections among antibody-diverse beef calves exposed to a bovine viral diarrhea virus persistently infected calf

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dc.contributor.author Nickell, Jason S.
dc.contributor.author White, Bradley J.
dc.contributor.author Larson, Robert L.
dc.contributor.author Renter, David G.
dc.contributor.author Roque, Julia
dc.contributor.author Hesse, Richard A.
dc.contributor.author Oberst, Richard D.
dc.contributor.author Peddireddi, Lalitha
dc.contributor.author Anderson, Gary A.
dc.date.accessioned 2012-10-02T16:53:40Z
dc.date.available 2012-10-02T16:53:40Z
dc.date.issued 2012-10-02
dc.identifier.uri http://hdl.handle.net/2097/14769
dc.description.abstract Persistently infected (PI) cattle are the reservoir of bovine viral diarrhea virus (BVDV), yet data describing BVDV transient infections (TI) among non-PI populations are minimal. Study objectives consisted of: 1. Estimating the onset and duration of TI based on serum VI and rRT-PCR, and 2. Determination of the potential of TI cattle to shed BVDV. Two 21-day studies were performed where one PI calf was commingled with a confirmed non-PI cattle population with heterogeneous BVDV antibody status (n=12 and n=15, respectively). After PI exposure, virus isolation on serum and nasal swabs failed to detect BVDV among non-PI cattle. Despite minimal disease (n=1), BVDV transmission occurred as 78% (n=21) of non-PI calves displayed a four-fold rise in BVDV antibody titers, 81.5% (n=22) displayed a transient positive serum BVDV rRT-PCR outcome, and 74.1% (n=20) displayed a transient positive rRT-PCR result on nasal swabs. Median days of positive serum rRT-PCR onset and duration were 10.0 (range: 6-21) and 3.0 (range: 1-9) days, respectively. These data suggest that non-PI cattle can become TI with minimal clinical disease while possessing the potential to transmit BVDV. The speed with which exposed cattle become transiently infected and their potential ability to shed the virus may impact design and implementation of BVDV control programs. en_US
dc.relation.uri http://www.jarvm.com/articles/Vol9Iss1/Vol9%20Iss1White.pdf en_US
dc.rights Permission to archive granted by the International Journal of Applied Research in Veterinary Medicine, September 8, 2012. en_US
dc.subject Bovine viral diarrhea virus en_US
dc.subject Cattle en_US
dc.subject Transient/acute infection en_US
dc.title Onset and duration of transient infections among antibody-diverse beef calves exposed to a bovine viral diarrhea virus persistently infected calf en_US
dc.type Article (publisher version) en_US
dc.date.published 2011 en_US
dc.citation.epage 39 en_US
dc.citation.issue 1 en_US
dc.citation.jtitle International Journal of Applied Research in Veterinary Medicine en_US
dc.citation.spage 29 en_US
dc.citation.volume 9 en_US
dc.contributor.authoreid whiteb en_US
dc.contributor.authoreid rlarson en_US
dc.contributor.authoreid drenter en_US
dc.contributor.authoreid jroque en_US
dc.contributor.authoreid rhesse en_US
dc.contributor.authoreid oberst en_US
dc.contributor.authoreid ganders en_US

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