Browsing Diagnostic Medicine/Pathobiology by Subject "Cultured cells"

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Combination of PB2 271A and SR polymorphism at positions 590/591 is critical for viral replication and virulence of swine influenza virus in cultured cells and in vivo

Liu, Qinfang; Qiao, Chuanling; Marjuki, Henju; Bawa, Bhupinder; Ma, Jingqun; Guillossou, Stephane; Webby, Richard J.; Richt, Juergen A.; Ma, Wenjun (2012-06-27)

Triple reassortant swine influenza viruses (SIVs) and 2009 pandemic H1N1 (pH1N1) virus contain an avian-origin PB2 with 271A, 590S, 591R, and 627E. To evaluate the role of PB2 271A, 590S, and 591R in the replication and ...