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Browsing Anatomy and Physiology by Published Date

Browsing Anatomy and Physiology by Published Date "2012"

Now showing items 1-13 of 13

Analyses of pig genomes provide insight into porcine demography and evolution

Groenen, Martien A. M.; Archibald, Alan L.; Uenishi, Hirohide; Tuggle, Christopher K.; Takeuchi, Yasuhiro; Rothschild, Max F.; Rogel-Gaillard, Claire; Blecha, Frank; Sang, Yongming (2012)

For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of ...
C1B domain peptide of protein kinase Cγ significantly suppresses growth of human colon cancer cells in vitro and in an in vivo mouse xenograft model through induction of cell cycle arrest and apoptosis

Kawabata, Atsushi; Matsuzuka, Takaya; Doi, Chiyo; Seiler, Garret; Reischman, Jennifer; Pickel, Lara; Ayuzawa, Rie; Nguyen, Thu A.; Tamura, Masaaki (2012)

Two peptides derived from the C1B domain of protein kinase Cγ (PKCγ) were shown to associate with classical PKC isozymes and modulate their activities. These C1B peptides are designated C1B1 (amino acid residues 101-112) ...
Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model

Basel, Matthew T.; Balivada, Sivasai; Wang, Hongwang; Shrestha, Tej B.; Seo, Gwi Moon; Pyle, Marla; Abayaweera, Gayani; Dani, Raj; Koper, Olga B.; Tamura, Masaaki; Chikan, Viktor; Bossmann, Stefan H.; Troyer, Deryl L. (2012)

Using magnetic nanoparticles to absorb alternating magnetic field energy as a method of generating localized hyperthermia has been shown to be a potential cancer treatment. This report demonstrates a system that uses tumor ...
Complete genome sequence of an overattenuated highly pathogenic porcine reproductive and respiratory syndrome virus

Wu, Jiajun; Chen, Nanhua; Han, Wei; Cao, Zhen; Deng, Xiaoyu; Wang, Lilin; Yu, Xiuling; Zhou, Zhi; Li, Xiangdong; Shi, Jishu; Tian, Kegong (2012)

JXA1-P170 is an overattenuated highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) that has been passaged in vitro 170 times. Vaccination with JXA1-P170 cannot protect pigs against JXA1 challenge. ...
Complete genome sequence of two novel Chinese virulent porcine reproductive and respiratory syndrome virus variants

Zhou, Zhi; Li, Xiangdong; Liu, Qi; Hu, Dongmei; Yue, Xiaojuan; Ni, Jianqiang; Yu, Xiuling; Zhai, Xinyan; Galliher-Beckley, Amy; Chen, Nanhua; Shi, Jishu; Tian, Kegong (2012)

A highly pathogenic strain of porcine reproductive and respiratory syndrome virus (PRRSV), characterized by a discontinuous 30-amino-acid deletion in its Nsp2-coding region, has been emerging in China since 2006. Here, ...
IL-1β promotes stemness and invasiveness of colon cancer cells through Zeb1 activation

Li, Yijing; Wang, Lei; Pappan, Loretta; Galliher-Beckley, Amy; Shi, Jishu (2012)

Background: IL-1β is a pleiotropic pro-inflammatory cytokine and its up-regulation is closely associated with various cancers including gastrointestinal tumors. However, it remains unclear how IL-1β may contribute to the ...
Interleukin-1 beta and transforming growth factor-beta cooperate to induce neurosphere formation and increase tumorigenicity of adherent LN-229 glioma cells

Wang, Lei; Liu, Ziyan; Balivada, Sivasai; Shrestha, Tej; Bossmann, Stefan H.; Pyle, Marla; Pappan, Loretta; Shi, Jishu; Troyer, Deryl L. (2012)

Introduction: Glioma stem cells (GSCs) have the property of self-renewal and appear to be a driving force for the initiation and recurrence of gliomas. We recently found that the human tumorigenic LN-229 glioma cell line ...
Intratracheal administration of a nanoparticle-based therapy with the angiotensin II type 2 receptor gene attenuates lung cancer growth

Kawabata, Atsushi; Baoum, Abdulgader; Ohta, Naomi; Jacquez, Stephanie; Seo, Gwi-Moon; Berkland, Cory; Tamura, Masaaki (2012)

Targeted gene delivery, transfection efficiency and toxicity concerns remain a challenge for effective gene therapy. In this study, we dimerized the HIV-1 TAT peptide and formulated a nanoparticle vector (dTAT NP) to ...
Na+ absorption by Claudius’ cells is regulated by purinergic signaling in the cochlea

Yoo, Jae Chul; Kim, Hye-Young; Han, Kyu-Hee; Oh, Seung Ha; Chang, Sun O; Marcus, Daniel C.; Lee, Jun Ho (2012)

Conclusion: Claudius’ cells absorb Na+ through the amiloride-sensitive epithelial sodium channel (ENaC). Transepithelial ion transport through ENaC and possibly a Cl[superscript]- secretory pathway is regulated by P2Y ...
PR-39, a porcine host defence peptide, is prominent in mucosa and lymphatic tissue of the respiratory tract in healthy pigs and pigs infected with actinobacillus pleuropneumoniae

Hennig-Pauka, Isabel; Koch, Rüdiger; Hoeltig, Doris; Gerlach, Gerald-F; Waldmann, Karl-Heinz; Blecha, Frank; Brauer, Carsten; Gasse, Hagen (2012)

Background: Host defence peptides are important components of mammalian innate immunity. We have previously shown that PR-39, a cathelicidin host defence peptide, is an important factor in porcine innate immune mechanisms ...
Pro-inflammatory cytokine interleukin-1β promotes the development of intestinal stem cells

Wang, Lei; Liu, Ziyan; Li, Yijing; Pappan, Loretta; Galliher-Beckley, Amy; Shi, Jishu (2012)

Objective: We investigated the effect of IL-1β on the development of intestinal epithelial stem cells. Materials and methods: Normal intestinal epithelial cell line IEC-18 cells were cultured in the presence or absence of ...
Replication-competent recombinant porcine reproductive and respiratory syndrome (PRRS) viruses expressing indicator proteins and antiviral cytokines

Sang, Yongming; Shi, Jishu; Sang, Wenjing; Rowland, Raymond R. R.; Blecha, Frank (2012)

Porcine reproductive and respiratory syndrome virus (PRRSV) can subvert early innate immunity, which leads to ineffective antimicrobial responses. Overcoming immune subversion is critical for developing vaccines and other ...
Stem cell-based photodynamic therapy

Shrestha, Tej B.; Seo, Gwi M.; Basel, Matthew T.; Kalita, Mausam; Wang, Hongwang; Villanueva, David; Pyle, Marla; Troyer, Deryl L.; Bossmann, Stefan H. (2012)

We have transfected murine neural stem cells (NSCs) and rat umbilical cord matrix-derived stem cells (RUCMSCs) with a plasmid expressing gaussia luciferase (gLuc). These cells are engineered to secrete the luciferase. We ...

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