Plasticity of microvascular oxygenation control in rat fast-twitch muscle: effects of experimental creatine depletion

K-REx Repository

Show simple item record

dc.contributor.author McDonough, Paul
dc.contributor.author Padilla, Danielle J.
dc.contributor.author Kano, Yutaka
dc.contributor.author Musch, Timothy I.
dc.contributor.author Poole, David C.
dc.contributor.author Behnke, Brad J.
dc.date.accessioned 2012-06-14T14:17:11Z
dc.date.available 2012-06-14T14:17:11Z
dc.date.issued 2012-06-14
dc.identifier.uri http://hdl.handle.net/2097/13933
dc.description.abstract Aging, heart failure and diabetes each compromise the matching of O2 delivery (QO2)-to-metabolic requirements (O2 uptake, VO2) in skeletal muscle such that the O2 pressure driving blood-myocyte O2 flux (microvascular PO2, PmvO2) is reduced and contractile function impaired. In contrast, β-guanidinopropionic acid (β-GPA) treatment improves muscle contractile function, primarily in fast-twitch muscle (Moerland and Kushmerick, 1994). We tested the hypothesis that β-GPA (2% wt/BW in rat chow, 8 wk; n=14) would improve QO2-to-VO2 matching (elevated PmvO2) during contractions (4.5 V @ 1 Hz) in mixed (MG) and white (WG) portions of the gastrocnemius, both predominantly fast-twitch). Compared with control (CON), during contractions PmvO2 fell less following β-GPA (MG -54%, WG -26%, p<0.05), elevating steady-state PmvO2 (CON, MG: 10±2, WG: 9±1; β-GPA, MG 16±2, WG 18±2 mmHg, P<0.05). This reflected an increased QO2/VO2 ratio due primarily to a reduced VO2 in β-GPA muscles. It is likely that this adaptation helps facilitate the β-GPA-induced enhancement of contractile function in fast-twitch muscles. en_US
dc.relation.uri http://www.sciencedirect.com/science/journal/15699048/181/1 en_US
dc.subject β-guanidinopropionic acid en_US
dc.subject Microvascular O2 exchange en_US
dc.subject Muscle fiber type en_US
dc.subject O2 extraction en_US
dc.subject Phosphorescence quenching en_US
dc.title Plasticity of microvascular oxygenation control in rat fast-twitch muscle: effects of experimental creatine depletion en_US
dc.type Article (author version) en_US
dc.date.published 2012 en_US
dc.citation.doi doi:10.1016/j.resp.2012.01.003 en_US
dc.citation.epage 20 en_US
dc.citation.issue 1 en_US
dc.citation.jtitle Respiratory Physiology & Neurobiology en_US
dc.citation.spage 14 en_US
dc.citation.volume 181 en_US
dc.contributor.authoreid dcpoole en_US
dc.contributor.authoreid musch en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search K-REx


Advanced Search

Browse

My Account








Center for the

Advancement of Digital

Scholarship

118 Hale Library

Manhattan KS 66506


(785) 532-7444

cads@k-state.edu