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Anatomy and Physiology Faculty Research and Publications

Anatomy and Physiology Faculty Research and Publications

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Interaction between innate immunity and porcine reproductive and respiratory syndrome virus

Sang, Yongming; Rowland, Raymond R. R.; Blecha, Frank (2011)

Innate immunity provides frontline antiviral protection and bridges adaptive immunity against virus infections. However, viruses can evade innate immune surveillance potentially causing chronic infections that may lead to ...
Analyses of pig genomes provide insight into porcine demography and evolution

Groenen, Martien A. M.; Archibald, Alan L.; Uenishi, Hirohide; Tuggle, Christopher K.; Takeuchi, Yasuhiro; Rothschild, Max F.; Rogel-Gaillard, Claire; Blecha, Frank; Sang, Yongming (2012)

For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of ...
Replication-competent recombinant porcine reproductive and respiratory syndrome (PRRS) viruses expressing indicator proteins and antiviral cytokines

Sang, Yongming; Shi, Jishu; Sang, Wenjing; Rowland, Raymond R. R.; Blecha, Frank (2012)

Porcine reproductive and respiratory syndrome virus (PRRSV) can subvert early innate immunity, which leads to ineffective antimicrobial responses. Overcoming immune subversion is critical for developing vaccines and other ...
cAMP-stimulated Clˉ secretion is increased by glucocorticoids and inhibited by bumetanide in semicircular canal duct epithelium

Pondugula, Satyanarayana R.; Kampalli, Suresh B.; Wu, Tao; De Lisle, Robert C.; Raveendran, Nithya N.; Harbidge, Donald G.; Marcus, Daniel C. (2013)

Background: The vestibular system controls the ion composition of its luminal fluid through several epithelial cell transport mechanisms under hormonal regulation. The semicircular canal duct (SCCD) epithelium has been ...
Naïve rat umbilical cord matrix stem cells significantly attenuate mammary tumor growth through modulation of endogenous immune responses

Kawabata, Atsushi; Ohta, Naomi; Seiler, Garret; Pyle, Marla M.; Ishiguro, Susumu; Zhang, Yongqing; Becker, Kevin G.; Troyer, Deryl L.; Tamura, Masaaki (2013)

Background: Un-engineered human and rat umbilical cord matrix stem cells (rUCMSC) attenuate growth of several types of tumors in mice and rats. However, the mechanism by which UCMSC attenuate tumor growth has not been ...

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