Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model

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dc.contributor.author Basel, Matthew T.
dc.contributor.author Balivada, Sivasai
dc.contributor.author Wang, Hongwang
dc.contributor.author Shrestha, Tej B.
dc.contributor.author Seo, Gwi Moon
dc.contributor.author Pyle, Marla
dc.contributor.author Abayaweera, Gayani
dc.contributor.author Dani, Raj
dc.contributor.author Koper, Olga B.
dc.contributor.author Tamura, Masaaki
dc.contributor.author Chikan, Viktor
dc.contributor.author Bossmann, Stefan H.
dc.contributor.author Troyer, Deryl L.
dc.date.accessioned 2012-05-24T13:43:12Z
dc.date.available 2012-05-24T13:43:12Z
dc.date.issued 2012-05-24
dc.identifier.uri http://hdl.handle.net/2097/13855
dc.description.abstract Using magnetic nanoparticles to absorb alternating magnetic field energy as a method of generating localized hyperthermia has been shown to be a potential cancer treatment. This report demonstrates a system that uses tumor homing cells to actively carry iron/iron oxide nanoparticles into tumor tissue for alternating magnetic field treatment. Paramagnetic iron/iron oxide nanoparticles were synthesized and loaded into RAW264.7 cells (mouse monocyte/macrophage-like cells), which have been shown to be tumor homing cells. A murine model of disseminated peritoneal pancreatic cancer was then generated by intraperitoneal injection of Pan02 cells. After tumor development, monocyte/macrophage-like cells loaded with iron/iron oxide nanoparticles were injected intraperitoneally and allowed to migrate into the tumor. Three days after injection, mice were exposed to an alternating magnetic field for 20 minutes to cause the cell-delivered nanoparticles to generate heat. This treatment regimen was repeated three times. A survival study demonstrated that this system can significantly increase survival in a murine pancreatic cancer model, with an average post-tumor insertion life expectancy increase of 31%. This system has the potential to become a useful method for specifically and actively delivering nanoparticles for local hyperthermia treatment of cancer. en_US
dc.relation.uri http://www.dovepress.com/cell-delivered-magnetic-nanoparticles-caused-hyperthermia-mediated-inc-peer-reviewed-article-IJN en_US
dc.subject Cytotherapy en_US
dc.subject Pancreatic cancer en_US
dc.subject Disseminated peritoneal carcinomatosis en_US
dc.subject Targeted magnetic hyperthermia en_US
dc.subject Nanoparticles en_US
dc.title Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model en_US
dc.type Article (publisher version) en_US
dc.date.published 2012 en_US
dc.citation.doi doi;10.2147/IJN.S28344 en_US
dc.citation.epage 306 en_US
dc.citation.jtitle International Journal of Nanomedicine en_US
dc.citation.spage 297 en_US
dc.citation.volume 7 en_US
dc.contributor.authoreid mbasel en_US
dc.contributor.authoreid sivasai en_US
dc.contributor.authoreid hongwang en_US
dc.contributor.authoreid tbs3 en_US
dc.contributor.authoreid mpyle en_US
dc.contributor.authoreid gayani en_US
dc.contributor.authoreid rdani en_US
dc.contributor.authoreid okoper en_US
dc.contributor.authoreid masaakit en_US
dc.contributor.authoreid chikan en_US
dc.contributor.authoreid sbossman en_US
dc.contributor.authoreid troyer en_US

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