Aldose reductase inhibitors and nanodelivery of diabetic therapeutics

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dc.contributor.author Prior, Allan M.
dc.contributor.author Thapa, Mahendra
dc.contributor.author Hua, Duy H.
dc.date.accessioned 2012-04-18T16:30:49Z
dc.date.available 2012-04-18T16:30:49Z
dc.date.issued 2012-04-18
dc.identifier.uri http://hdl.handle.net/2097/13611
dc.description.abstract Nanotechnology is a rapidly emerging drug-delivery system that makes possible the controlled release of small molecules, and nanodelivery of therapeutic molecules using nanoparticles or nanogels represents a major improvement for more focused delivery of such therapeutic molecules. The delivery of insulin for the control of diabetes mellitus (DM) and aldose reductase inhibitor (ARI) for diabetic complications may provide better treatment of diabetes. A structural overview of aldose reductase including computational docking experiments with HAR-1, various ARIs, aldose-keto reductase, and nanodelivery of insulin, ARI’s, and drug molecules are described. en_US
dc.relation.uri http://www.benthamscience.com/openaccessplus.php?JCode=MRMC en_US
dc.subject Aldose reductase en_US
dc.subject Aldose reductase inhibitors en_US
dc.subject Aldo-keto reductase en_US
dc.subject Diabetes en_US
dc.subject Insulin en_US
dc.subject Nanodelivery en_US
dc.subject Nanogels en_US
dc.subject Tricyclic pyrone molecules en_US
dc.title Aldose reductase inhibitors and nanodelivery of diabetic therapeutics en_US
dc.type Article (author version) en_US
dc.date.published 2012 en_US
dc.citation.epage 336 en_US
dc.citation.issue 4 en_US
dc.citation.jtitle Mini-Reviews in Medicinal Chemistry en_US
dc.citation.spage 326 en_US
dc.citation.volume 12 en_US
dc.contributor.authoreid duy en_US

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