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Human Nutrition >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/2097/1308
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| Title: | Are the health attributes of lycopene related to its antioxidant function? |
| Authors: | Erdman, John W. Jr.
Ford, Nikki A.
Lindshield, Brian L. |
| Publication Date: | 2009 |
| Type: | Article (author version) |
| Journal: | Archives of biochemistry and biophysics |
| Volume: | 483 |
| Issue: | 2 |
| Starting Page: | 229 |
| Ending Page: | 235 |
| Keywords: | Lycopene
Lycopenoids
Carotenoids
Antioxidant
Prostate cancer
Oxidative stress
Cardiovascular disease
Vitamin E
Mechanism |
| Abstract: | A variety of epidemiological trials have suggested that higher intake of lycopene-containing foods (primarily tomato products) or blood lycopene concentrations are associated with decreased cardiovascular disease and prostate cancer risk. Of the carotenoids tested, lycopene has been demonstrated to be the most potent in vitro antioxidant leading many researchers to conclude that the antioxidant properties of lycopene are responsible for disease prevention. In our review of human and animal trials with lycopene, or lycopene-containing extracts, there is limited support for the in vivo antioxidant function for lycopene. Moreover, tissue levels of lycopene appear to be too low to play a meaningful antioxidant role. We conclude that there is an overall shortage of supportive evidence for the "antioxidant hypothesis" as lycopene's major in vivo mechanism of action. Our laboratory has postulated that metabolic products of lycopene, the lycopenoids, may be responsible for some of lycopene's reported bioactivity. |
| URI: | http://hdl.handle.net/2097/1308 |
| Appears in Collections: | Human Nutrition
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