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Biochemistry Faculty Research and Publications

Biochemistry Faculty Research and Publications

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Retroactive maintains cuticle integrity by promoting the trafficking of Knickkopf into the procuticle of Tribolium castaneum

Chaudhari, Sujata S.; Arakane, Yasuyuki; Specht, Charles A.; Moussian, Bernard; Kramer, Karl J.; Muthukrishnan, Subbaratnam; Beeman, Richard W. (2013)

Molting, or the replacement of the old exoskeleton with a new cuticle, is a complex developmental process that all insects must undergo to allow unhindered growth and development. Prior to each molt, the developing new ...
Potential conformational heterogeneity of p53 bound to S100B(ββ)

McDowell, Chester; Chen, Jianlin; Chen, Jianhan (2013)

The negative regulatory domain (NRD) of the p53 tumor suppressor is intrinsically disordered. It contains several post-translational modification (PTM) sites that are important for regulation of p53 activity. Calcium-dependent ...
An initial event in insect innate immune response: structural and biological studies of interactions between β-1,3-glucan and the N-terminal domain of β-1,3-glucan recognition protein

Dai, Huaien; Hiromasa, Yasuaki; Takahashi, Daisuke; VanderVelde, David; Fabrick, Jeffrey A.; Kanost, Michael R.; Krishnamoorthi, Ramaswamy (2013)

In response to invading microorganisms, insect β-1,3-glucan recognition protein (βGRP), a soluble receptor in the hemolymph, binds to the surfaces of bacteria and fungi and activates serine protease cascades that promote ...
Role of catecholate siderophores in gram-negative bacterial colonization of the mouse gut

Pi, Hualiang; Jones, Shari A.; Mercer, Lynn E.; Meador, Jessica P.; Caughron, Joyce E.; Jordan, Lorne; Newton, Salete M.; Conway, Tyrrell; Klebba, Phillip E. (2012)

We investigated the importance of the production of catecholate siderophores, and the utilization of their iron (III) complexes, to colonization of the mouse intestinal tract by Escherichia coli. First, a ΔtonB strain was ...
Chemical warfare agent simulants in Gamble’s fluid: Is the fluid toxic? Can it be made safer by inclusion of solid nanocrystalline metal oxides?

Karote, Dennis; Walker, Brandon; Dai, Huaien; Krishnamoorthi, Ramaswamy; Voo, Janis; Rajagopalan, Shyamala (2013)

The reactions of chemical warfare agent simulants, 2-chloroethyl ethyl sulfide (2-CEES) and di-i-propyl fluoro phosphate (DFP), in fluids have been investigated. Data analyses confirm the major degradation pathway to be ...

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