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Browsing Chemistry Faculty Research and Publications by Title

Browsing Chemistry Faculty Research and Publications by Title

Now showing items 30-47 of 80

Gaussian and non-Gaussian fluctuations in pure classical fluids

Naleem, Nawavi; Ploetz, Elizabeth A.; Smith, Paul E.

The particle number, energy, and volume probability distributions in the canonical, isothermal-isobaric, grand canonical, and isobaric-isenthalpic ensembles are investigated. In particular, we consider Gaussian and ...
Graphene/GaSe-Nanosheet Hybrid: Towards High Gain and Fast Photoresponse

Lu, R. T.; Liu, J. W.; Luo, H. F.; Chikan, Viktor; Wu, J. Z.

While high photoconductive gain has been recently achieved in graphene-based hybrid phototransistors using semiconductor two-dimensional transition/post-transition metal dichalcogenides or quantum dots sensitizers, obtaining ...
Incorporating I-131 into a PAMAM (G5.0) dendrimerconjugate: design of a theranostic nanosensor for medullary thyroid carcinoma

He, R.; Wang, H.; Su, Y.; Chen, C.; Xie, L.; Chen, L.; Yu, J.; Toledo, Y.; Abayaweera, G. S.; Zhu, G.; Bossmann, Stefan H.

We report the synthesis and purification of a targeting probe for Medullary Thyroid Carcinoma (MTC) by incorporating I-131 into PAMAM (G5.0) dendrimers. Both the I-131 labeled control dendrimer (I-131-PAMAM (G5.0) without ...
Inhibition of ACAT, overexpression of cholesterol transporter gene, and protection of amyloid β oligomers-induced neuronal cell death by tricyclic pyrone molecules

Pokhrel, Laxman; Maezawa, Izumi; Nguyen, Thi D.T.; Chang, Kyeong-Ok; Jin, Lee-Way; Hua, Duy H. (2012-12-11)

Alzheimer’s disease (AD) is the most common cause of dementia in the elderly. A major effort in AD therapeutic development has targeted Aβ and downstream events. We have taken a rational design approach and synthesized a ...
Inhibition of long chain fatty acyl-CoA synthetase (ACSL) and ischemia reperfusion injury

Prior, Allan M.; Zhang, Man; Blakeman, Nina; Datta, Palika; Pham, Hung; Chen, Qian; Young, Lindon H.; Weis, Margaret T.; Hua, Duy H. (2014-05-30)

Various triacsin C analogs, containing different alkenyl chains and carboxylic acid bioisoteres including 4-aminobenzoic acid, isothiazolidine dioxide, hydroxylamine, hydroxytriazene, and oxadiazolidine dione, were synthesized ...
Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors

Mandadapu, Sivakoteswara Rao; Gunnam, Mallikarjuna Reddy; Tiew, Kok-Chuan; Uy, Roxanne Adeline Z.; Prior, Allan M.; Alliston, Kevin R.; Hua, Duy H.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C. (2012-12-18)

Noroviruses are the most common cause of acute viral gastroenteritis, accounting for >21 million cases annually in the U.S. alone. Norovirus infections constitute an important health problem for which there are no specific ...
Interdependence of structure and physical properties in co-crystals of azopyridines

Aakeröy, Christer B.; Panikkattu, Sheelu; DeHaven, Baillie; Desper, John (2013-07-16)

To establish how intermolecular interactions influence the supramolecular assembly of azopyridines, a total of five co-crystals of 3,3′ and 4,4′-azopyridine; 3,3′-azpy:succinic acid (3,3′-azpy:SA), 3,3′-azpy:adipic acid ...
Is there any point in making co-crystals?

Aakeröy, Christer B.
Kinetic properties of alternatively spliced isoforms of laccase-2 from Tribolium castaneum and Anopheles gambiae

Gorman, Maureen J.; Sullivan, Lucinda I.; Nguyen, Thi D.T.; Dai, Huaien; Arakane, Yasuyuki; Dittmer, Neal T.; Syed, Lateef U.; Li, Jun; Hua, Duy H.; Kanost, Michael R. (2012-05-11)

Laccase-2 is a highly conserved multicopper oxidase that functions in insect cuticle pigmentation and tanning. In many species, alternative splicing gives rise to two laccase-2 isoforms. A comparison of laccase-2 sequences ...
Kirkwood–Buff integrals for ideal solutions

Ploetz, Elizabeth A.; Bentenitis, Nikolaos; Smith, Paul E. (2011-08-18)

The Kirkwood–Buff (KB) theory of solutions is a rigorous theory of solution mixtures which relates the molecular distributions between the solution components to the thermodynamic properties of the mixture. Ideal solutions ...
Kirkwood–Buff theory of four and higher component mixtures

Kang, Myungshim; Smith, Paul E. (2011-08-18)

Explicit expressions are developed for the chemical potential derivatives, partial molar volumes, and isothermal compressibility of solution mixtures involving four components at finite concentrations using the Kirkwood–Buff ...
Kirkwood–Buff theory of molecular and protein association, aggregation, and cellular crowding

Gee, Moon Bae; Smith, Paul E. (2011-08-18)

An analysis of the effect of a cosolvent on the association of a solute in solution using the Kirkwood–Buff theory of solutions is presented. The approach builds on the previous results of Ben-Naim by extending the range ...
Label-free electrochemical impedance detection of kinase and phosphatase activities using carbon nanofiber nanoelectrode arrays

Li, Yi Fen; Syed, Lateef; Liu, Jianwei; Hua, Duy H.; Li, Jun (2012-09-26)

We demonstrate the feasibility of a label-free electrochemical method to detect the kinetics of phosphorylation and dephosphorylation of surface-attached peptides catalyzed by kinase and phosphatase, respectively. The ...
Local fluctuations in solution mixtures

Ploetz, Elizabeth A.; Smith, Paul E. (2011-08-22)

An extension of the traditional Kirkwood-Buff (KB) theory of solutions is outlined which provides additional fluctuating quantities that can be used to characterize and probe the behavior of solution mixtures. Particle-energy ...
Long-range modulation of a composite crystal in a five-dimensional superspace

Guerin, L.; Mariette, C.; Rabiller, P.; Huard, M.; Ravy, S.; Fertey, P.; Nichols, S. M.; Wang, B.; Mannsfeld, S. C. B.; Weber, T.; Hollingsworth, Mark D.; Toudic, B.
Luminol-based bioluminescence imaging of mouse mammary tumors

Alshetaiwi, Hamad S.; Balivada, Sivasai; Shrestha, Tej Bahadur; Pyle, Marla M.; Basel, Matthew T.; Bossmann, Stefan H.; Troyer, Deryl L. (2014-01-24)

Polymorphonuclear neutrophils (PMNs) are the most abundant circulating blood leukocytes. They are part of the innate immune system and provide a first line of defense by migrating toward areas of inflammation in response ...
Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus

Mandadapu, Sivakoteswara Rao; Weerawarna, Pathum M.; Prior, Allan M.; Uy, Roxanne Adeline Z.; Aravapalli, Sridhar; Alliston, Kevin R.; Lushington, Gerald H.; Kim, Yunjeong; Hua, Duy H.; Chang, Kyeong-Ok; Groutas, William C. (2013-09-06)

The design, synthesis, and in vitro evaluation of the first macrocyclic inhibitor of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus are reported. The in vitro inhibitory activity (50% effective ...
Magnetic-Fe/Fe3O4-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

Wang, Hongwang; Shrestha, Tej Bahadur; Basel, Matthew T.; Dani, Raj K.; Seo, Gwi-Moon; Balivada, Sivasai; Pyle, Marla M.; Prock, Heidy; Koper, Olga B.; Thapa, Prem S.; Moore, David; Li, Ping; Chikan, Viktor; Troyer, Deryl L.; Bossmann, Stefan H. (2012-07-26)

The targeted delivery of therapeutics to the tumor site is highly desirable in cancer treatment, because it is capable of minimizing collateral damage. Herein, we report the synthesis of a nanoplatform, which is composed ...