Chemistry

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Chemistry

 

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  • Aakeröy, Christer B.; Forbes, Safiyyah; Desper, John (2014)
    Systematic structure-property studies on a series of co-crystals of potential cancer drugs with aliphatic dicarboxylic acids were undertaken. This study reveals that systematic changes to the molecular nature of the ...
  • Aakeröy, Christer B.; Chopade, Prashant D.; Quinn, Colette F.; Desper, John (2014)
    A set of COOH···N(pyridine) 5 hydrogen bonds have been utilized in the targeted synthesis of a cavitand-based assembly. A cavitand appended with four pyridyl groups was synthesized from a Suzuki coupling of a tetrabromocavitand ...
  • Prior, Allan M.; Zhang, Man; Blakeman, Nina; Datta, Palika; Pham, Hung; Chen, Qian; Young, Lindon H.; Weis, Margaret T.; Hua, Duy H. (2014)
    Various triacsin C analogs, containing different alkenyl chains and carboxylic acid bioisoteres including 4-aminobenzoic acid, isothiazolidine dioxide, hydroxylamine, hydroxytriazene, and oxadiazolidine dione, were synthesized ...
  • Prior, Allan M.; Kim, Yunjeong; Weerasekara, Sahani; Moroze, Meghan; Alliston, Kevin R.; Uy, Roxanne Adeline Z.; Groutas, William C.; Chang, Kyeong-Ok; Hua, Duy H. (2013)
    A class of tripeptidyl transition state inhibitors containing a P1 glutamine surrogate, a P2 leucine, and a P3 arylalanines, was found to potently inhibit Norwalk virus replication in enzyme and cell based assays. An array ...
  • Alshetaiwi, Hamad S.; Balivada, Sivasai; Shrestha, Tej B.; Pyle, Marla M.; Basel, Matthew T.; Bossmann, Stefan H.; Troyer, Deryl L. (2013)
    Polymorphonuclear neutrophils (PMNs) are the most abundant circulating blood leukocytes. They are part of the innate immune system and provide a first line of defense by migrating toward areas of inflammation in response ...