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College of Human Ecology >
Human Nutrition >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/2097/1009
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| Title: | Lycopenoids: Are lycopene metabolites bioactive? |
| Authors: | Lindshield, Brian L.
Canene-Adams, Kirstie
Erdman, John W. Jr. |
| Publication Date: | 2007 |
| Type: | Article (author version) |
| Journal: | Archives of biochemistry and biophysics |
| Volume: | 458 |
| Starting Page: | 136 |
| Ending Page: | 140 |
| Keywords: | Lycopenoids
Lycopene
Prostate cancer
Carotenoids
Tomato
Carotenoid monooxygenase
CMO
Beta-carotene
Phytoene
Phytofluene |
| Abstract: | In vitro lycopene is the most potent antioxidant among carotenoids. While antioxidant function may be relevant to health, we hypothesize that metabolites of lycopene may be bioactive and responsible for the beneficial effects of tomato product consumption. We term these metabolites "lycopenoids," which we believe may be produced from carotenoid monooxygenase (CMO) II, paralleling the production of retinoids from [beta]-carotene by CMO I. We present evidence suggesting that tomato carotenoid metabolites may be responsible for the reduced risk of prostate cancer seen in men consuming high levels of tomato products. Finally, we identify gaps in knowledge in this evolving area of carotenoid research. |
| URI: | http://hdl.handle.net/2097/1009 |
| Publisher URL: | http://www.elsevier.com/wps/find/journaldescription.cws_home/622787/description#description |
| Appears in Collections: | Human Nutrition
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