Notch receptors are core components of the Notch signaling pathway and play a central role in cell fate decisions during development as well as tissue homeostasis. Upon ligand binding, Notch is sequentially cleaved at the ...

The negative regulatory domain (NRD) of the p53 tumor suppressor is intrinsically disordered. It contains several post-translational modification (PTM) sites that are important for regulation of p53 activity. Calcium-dependent ...

Intrinsically disordered proteins (IDPs) lack stable structures under physiological conditions but often fold into stable structures upon specific binding. These coupled binding and folding processes underlie the organization ...